用于治疗癌症的基因修饰细胞

Gene-modified cells for the treatment of cancer.

作者信息

Whartenby K A, Abraham G N, Calabresi P A, Abboud C N, Calabresi P, Marrogi A, Freeman S M

机构信息

Department of Medicine, University of Rochester Medical Center, NY 14642, USA.

出版信息

Pharmacol Ther. 1995 Apr;66(1):175-90. doi: 10.1016/0163-7258(94)00081-d.

DOI:10.1016/0163-7258(94)00081-d

PMID:7630929

Abstract

Gene therapy involves the insertion of a gene into an organism to treat a disease. Since its early development in the 1970s, gene therapy has expanded rapidly both in terms of the methods available and the number of candidate diseases for treatment. This report reviews gene therapy for cancer, including methodology, pre-clinical studies and experimental clinical trials.

摘要

基因治疗是指将基因导入生物体以治疗疾病。自20世纪70年代早期发展以来，基因治疗在可用方法和候选治疗疾病数量方面都迅速扩展。本报告回顾了癌症的基因治疗，包括方法学、临床前研究和实验性临床试验。