Kristensen K S, Bang L E, Høegholm A, Nielsen J W, Holm J
Medicinsk afdeling, Centralsygehuset i Naestved.
Ugeskr Laeger. 1995 Jun 5;157(23):3322-5.
A prospective comparison of office blood pressure, daytime ambulatory blood pressure and urinary albumin excretion was performed in 284 consecutive patients from general practice with newly diagnosed, untreated mild to moderate hypertension. Based on daytime ambulatory blood pressure 173 were classified as established hypertensives and 111 as white coat hypertensives. A sample of 127 subjects drawn from the Danish national register served as a normotensive control group. It was found that urinary albumin/creatinine ratio differed significantly between the three groups; the difference remained significant after correction for covariables. Early morning urine albumin/creatinine ratio was weakly but significantly correlated to blood pressure. Early morning urine albumin/creatinine ratio was as reproducible a measure as 24-hour albumin excretion. It is concluded that white coat hypertensive patients have less renal involvement than patients with established hypertension, but more than a normotensive control group.
对284例来自全科医疗的新诊断、未经治疗的轻至中度高血压患者进行了诊室血压、日间动态血压和尿白蛋白排泄的前瞻性比较。根据日间动态血压，173例被分类为确诊高血压患者，111例为白大衣高血压患者。从丹麦国家登记处抽取的127名受试者样本作为正常血压对照组。结果发现，三组之间的尿白蛋白/肌酐比值存在显著差异；校正协变量后差异仍然显著。清晨尿白蛋白/肌酐比值与血压呈弱但显著的相关性。清晨尿白蛋白/肌酐比值与24小时白蛋白排泄量一样是可重复的测量指标。结论是，白大衣高血压患者的肾脏受累程度低于确诊高血压患者，但高于正常血压对照组。
