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[坏死性小肠结肠炎。在丹麦西部的发病率]

[Necrotizing enterocolitis. Occurrence in Western Denmark].

作者信息

Andreassen B U, Andersen K, Ebbesen F

机构信息

Børneafdelingen, Aalborg Sygehus.

出版信息

Ugeskr Laeger. 1995 Jun 5;157(23):3326-30.

PMID:7631441
Abstract

We reviewed the clinical presentation, subsequent course and outcome of 45 newborn infants with neuotizing enterocolitis (NEC) seen on eight neonatal intensive care units during a 10 year period (01.01.82-31.12.91). The average incidence of NEC was found to be 1.2 (0.3-3.8) per 10,000 liveborn infants with a tendency to increase during the period. Eighteen percent had a birth weight of less than 1,000 g. Thirty-six percent had a birthweight between 1,000 and 1,500 g. Twenty-nine percent had a birthweight between 1,500 and 2,500 g. The last group made up of 16% had birth weights above 2,500 g. The mortality was determined by the severity of the disease, being 0% for infants within Bell's stage I, 25% in Bell's stage II and 71% in Bell's stage III. Sixty-nine percent of the infants were diagnosed in stage III, probably because of low attention to NEC in its early stages. The prognosis of surviving infants was good with no gastrointestinal symptoms when evaluated four to five years later.

摘要

我们回顾了在10年期间(1982年1月1日至1991年12月31日)于8个新生儿重症监护病房收治的45例患有坏死性小肠结肠炎(NEC)的新生儿的临床表现、后续病程及转归。发现NEC的平均发病率为每10,000例活产婴儿中有1.2例(0.3 - 3.8例),且在此期间有上升趋势。18%的婴儿出生体重低于1000克。36%的婴儿出生体重在1000至1500克之间。29%的婴儿出生体重在1500至2500克之间。最后一组占16%,出生体重高于2500克。死亡率取决于疾病的严重程度,贝尔I期婴儿的死亡率为0%,贝尔II期为25%,贝尔III期为71%。69%的婴儿在III期被诊断出来,这可能是因为早期对NEC的关注度较低。在4至5年后进行评估时,存活婴儿的预后良好,无胃肠道症状。

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