Nebbia C, Dacasto M, Valenza F, Burdino E, Ugazio G, Fink-Gremmels J
Department of Animal Pathology, University of Turin, Italy.
Vet Hum Toxicol. 1995 Apr;37(2):137-42.
The effects of subchronic administration (90 d) of zineb were studied in male New Zealand White rabbits. Rabbits were allotted to 3 groups of 8 animals each and offered diets containing 0, 0.3 or 0.6% zineb. A marked decline in weight gain, hemoglobin concentration, hematocrit, and erythrocyte and leucocyte counts occurred at the highest zineb dosage. There was a dose-related depression in circulating thyroid hormones, whereas serum lipid concentration, particularly that of cholesterol and triglycerides, increased. Hepatic lipid concentration was considerably reduced in rabbits exposed to 0.6% zineb. Neither serum testosterone nor the activities of selected testicular enzymes showed changes suggestive of testicular involvement. Pathological changes were in agreement with biochemical findings; there was a marked dose-related enlargement of the thyroid showing histological colloid struma. An increase in relative weight and moderate glycogenosis were detected in liver, whereas no lesions occurred in testes. It was concluded that thyroid and liver are the main targets for zineb toxicity in the rabbit. Unlike the results from previous studies conducted on other food-producing species, repeated exposure of rabbits to zineb failed to cause testicular damage. This might be related to the inability of zineb to significantly accumulate in the testes.
在雄性新西兰白兔中研究了代森锌亚慢性给药（90天）的影响。将兔子分成3组，每组8只动物，分别给予含0%、0.3%或0.6%代森锌的日粮。在最高代森锌剂量下，体重增加、血红蛋白浓度、血细胞比容以及红细胞和白细胞计数均显著下降。循环甲状腺激素出现剂量相关的降低，而血清脂质浓度，尤其是胆固醇和甘油三酯的浓度升高。暴露于0.6%代森锌的兔子肝脏脂质浓度显著降低。血清睾酮和所选睾丸酶的活性均未显示出提示睾丸受累的变化。病理变化与生化结果一致；甲状腺出现明显的剂量相关肿大，表现为组织学上的胶体甲状腺肿。肝脏相对重量增加且出现中度糖原沉积，而睾丸未出现病变。得出的结论是，甲状腺和肝脏是代森锌对兔子毒性作用的主要靶器官。与之前对其他产食用动物物种进行的研究结果不同，兔子反复接触代森锌未导致睾丸损伤。这可能与代森锌无法在睾丸中显著蓄积有关。
