Murotsuki J, Challis J R, Johnston L, Gagnon R
Department of Obstetrics and Gynaecology, St. Joseph's Health Centre, Lawson Research Institute, University of Western Ontario, London, Canada.
Am J Obstet Gynecol. 1995 Jul;173(1):30-5. doi: 10.1016/0002-9378(95)90165-5.
The purpose of this study was to examine the effect of chronic fetal placental embolization on fetal plasma prostaglandin E2 concentrations.
Fourteen pregnant sheep were studied (seven embolized and seven controls) for 10 days between 0.84 and 0.91 of gestation. Daily injections of nonradioactive microspheres were made to decrease fetal arterial oxygen content by 30% to 35% of preembolization values.
In response to repeated embolization, fetal plasma prostaglandin E2 concentrations increased significantly on day 1, declined to near control levels on days 2 to 6, but were significantly elevated again after day 7. Maternal prostaglandin E2 levels remained unchanged throughout the study. Fetal plasma prostaglandin E2 levels increased significantly with decreasing fetal oxygenation when fetal arterial oxygen content was < 2.0 mmol/L.
We conclude that there is increased production of prostaglandin E2 by the placenta during progressive fetal hypoxemia induced by fetal placental embolization. We speculate that the progressive increase in prostaglandin E2 may be an important hormonal adaptive mechanism to maintain fetal homeostasis during the development of placental insufficiency.
本研究旨在探讨慢性胎儿胎盘栓塞对胎儿血浆前列腺素E2浓度的影响。
对14只怀孕绵羊（7只栓塞组和7只对照组）在妊娠0.84至0.91期间进行了10天的研究。每天注射非放射性微球，使胎儿动脉氧含量降低至栓塞前值的30%至35%。
反复栓塞后，胎儿血浆前列腺素E2浓度在第1天显著升高，在第2至6天降至接近对照组水平，但在第7天后再次显著升高。在整个研究过程中，母体前列腺素E2水平保持不变。当胎儿动脉氧含量<2.0 mmol/L时，胎儿血浆前列腺素E2水平随着胎儿氧合降低而显著升高。
我们得出结论，在胎儿胎盘栓塞诱导的进行性胎儿低氧血症期间，胎盘产生的前列腺素E2增加。我们推测，前列腺素E2的逐渐增加可能是在胎盘功能不全发展过程中维持胎儿内环境稳定的一种重要激素适应性机制。
