Grossman R F, Tu S H, Duh Q Y, Siperstein A E, Novosolov F, Clark O H
Department of Surgery, Mount Zion Medical Center, University of California at San Francisco, USA.
Arch Surg. 1995 Aug;130(8):892-7; discussion 898-9. doi: 10.1001/archsurg.1995.01430080094015.
To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of follicular cell origin.
Retrospective review.
University medical center.
Fourteen patients were treated for familial nonmedullary thyroid carcinoma between 1980 and 1994. Thirteen families were identified, with 30 affected individuals.
Patients were treated with total or completion total thyroidectomy. Thirteen additional operations were performed to control recurrent disease.
Stage, recurrence, and survival. Patients were followed up for a mean of 6.5 years.
In our 14 patients, 13 tumors were multifocal, and six of these were bilateral. The incidences of lymph node metastasis and local invasion were both 57% (n = 8). Seven patients (50%) had recurrences during follow-up.
Familial nonmedullary thyroid carcinoma has a high incidence of multifocality and invasion and a high rate of local recurrence. Aggressive initial treatment and careful follow-up seem to be indicated.
确定家族性非髓样甲状腺癌的生物学行为是否与散发性滤泡细胞源性癌相似。
回顾性研究。
大学医学中心。
1980年至1994年间，14例患者接受了家族性非髓样甲状腺癌的治疗。共识别出13个家族，30名患者受累。
患者接受了全甲状腺切除术或甲状腺次全切除术。另外进行了13次手术以控制复发疾病。
分期、复发和生存率。患者平均随访6.5年。
在我们的14例患者中，13例肿瘤为多灶性，其中6例为双侧性。淋巴结转移和局部侵犯的发生率均为57%（n = 8）。7例患者（50%）在随访期间复发。
家族性非髓样甲状腺癌多灶性和侵犯的发生率高，局部复发率高。似乎需要积极的初始治疗和仔细的随访。
