Frank M M, Hamburger M I, Lawley T J, Kimberly R P, Plotz P H
N Engl J Med. 1979 Mar 8;300(10):518-23. doi: 10.1056/NEJM197903083001002.
To determine whether reticuloendothelial-system immunospecific Fc-receptor function is abnormal in patients with systemic lupus erythematosus, we studied the clearance of IgG-sensitized 51Cr-labeled erythrocytes by these splenic macrophage membrane receptors in 15 untreated patients. Fc-specific clearance rates were strikingly abnormal in 13 of 15 patients (half-times ranging from 80 to 2256 minutes, P less than 0.001 as compared to controls). Abnormal clearances correlated with immune-complex levels (as measured by the C1q-binding assay) and with disease activity. C1q-binding activity and anti-DNA titers also correlated with disease activity. The correlations of C3, C4, CH50 and factor B with abnormal clearance and disease activity were weaker or nonexistent. The significant correlations among clearance, disease activity and C1q-binding activity suggest that the defect in Fc-receptor function may lead to the prolonged circulation of immune complexes, thereby contributing to tissue deposition and damage.
为了确定系统性红斑狼疮患者的网状内皮系统免疫特异性Fc受体功能是否异常，我们研究了15例未经治疗的患者脾脏巨噬细胞膜受体对IgG致敏的51Cr标记红细胞的清除情况。15例患者中有13例的Fc特异性清除率显著异常（半衰期为80至2256分钟，与对照组相比P小于0.001）。异常清除与免疫复合物水平（通过C1q结合试验测定）以及疾病活动度相关。C1q结合活性和抗DNA滴度也与疾病活动度相关。C3、C4、CH50和B因子与异常清除及疾病活动度的相关性较弱或不存在。清除率、疾病活动度和C1q结合活性之间的显著相关性表明，Fc受体功能缺陷可能导致免疫复合物循环时间延长，从而促使其在组织中沉积和造成损伤。
