Espino Hernandez M, Morales San Jose D, Luque de Pablos A
Paediatric Nephrology Unit, Hospital Gregorio Marañon, University of Madrid, Spain.
Pediatr Nephrol. 1995 Jun;9(3):357-8. doi: 10.1007/BF02254213.
We describe our preliminary experience with five children who received acetate-free biofiltration, a modification of haemodiafiltration without buffer in the dialysate and simultaneous infusion of bicarbonate through a venous port. Adequacy of haemodialysis (HD) was achieved with 3 h treatments three times per week (mean Kt/v 1.35 +/- 0.29, mean protein catabolic rate (PCR) 1.4 +/- 0.3 mg/dl). During the session, pH increased from 7.4 pre HD to 7.5 post HD. The mean bicarbonate infused as a 0.166 M solution averaged 235 +/- 35 mEq/h. Hypertension did not occur. There were no cramps, hypotension or vomiting. Bicarbonate requirements correlated significantly with dialyser surface area and body weight (r = 0.76, P < 0.001).
我们描述了5名接受无醋酸盐生物滤过治疗的儿童的初步经验，这是一种血液透析滤过的改良方法，透析液中无缓冲液，并通过静脉端口同时输注碳酸氢盐。每周进行3次3小时的治疗，达到了充分的血液透析（HD）（平均Kt/v 1.35±0.29，平均蛋白质分解代谢率（PCR）1.4±0.3mg/dl）。治疗期间，pH值从HD前的7.4升至HD后的7.5。作为0.166M溶液输注的平均碳酸氢盐量平均为235±35mEq/h。未发生高血压。未出现痉挛、低血压或呕吐。碳酸氢盐需求量与透析器表面积和体重显著相关（r = 0.76，P < 0.001）。
