Fagni L, Bockaert J
Mécanismes Moléculaires des Interactions Cellulaires, CNRS-UPR 9023, CCIPE, Montpellier, France.
Neuroreport. 1995 May 9;6(7):1037-40. doi: 10.1097/00001756-199505090-00022.
We investigated the mode of action of argiotoxin636 on isolated N-methyl-D-aspartate (NMDA) receptor channels in cultured cerebellar granule cells. We found that the toxin blocks NMDA channels by decreasing their opening probability and by inducing a flickering activity, in a voltage-dependent manner. Our results indicate that argiotoxin636 acts as an open-channel blocker and might therefore be a useful tool for studying the structure of glutamate-gated channels.
我们研究了精氨酸毒素636对培养的小脑颗粒细胞中分离出的N-甲基-D-天冬氨酸（NMDA）受体通道的作用方式。我们发现，该毒素通过降低NMDA通道的开放概率并诱导闪烁活动，以电压依赖性方式阻断NMDA通道。我们的结果表明，精氨酸毒素636作为一种开放通道阻滞剂，因此可能是研究谷氨酸门控通道结构的有用工具。
