Wagner B K, Amory D W, Majcher C M, DiFazio L T, Scott G E, Spotnitz A J
Department of Pharmacy Practice and Administration, Rutgers College of Pharmacy, Piscataway, NJ, USA.
Ann Pharmacother. 1995 Apr;29(4):349-53. doi: 10.1177/106002809502900401.
To determine the effects of cardiopulmonary bypass and famotidine on gastric acid secretion in adults undergoing cardiac surgery.
Prospective, randomized, double-blind, placebo-controlled study.
University teaching hospital.
Eighteen patients undergoing elective cardiac surgery with cardiopulmonary bypass.
Famotidine 20 mg or NaCl 0.9% placebo was administered intravenously following induction of anesthesia and placement of a nasogastric pH probe. A second dose was given 12 hours after surgery in the intensive care unit. Gastric pH was measured continuously and gastric volume was measured every 4 hours for up to 24 hours after cardiopulmonary bypass.
Following famotidine administration, pH increased by 43% within 45 minutes and remained above 5.5 throughout the study period (p < 0.05 vs placebo and baseline). The gastric pH did not increase, but remained above 4.0 in most patients in the placebo group for up to 12 hours after cardiopulmonary bypass. Gastric volumes were on average 24% lower in the famotidine group (p > 0.05).
Gastric acid secretion is decreased during and for 12 hours after cardiopulmonary bypass. Perioperative administration of famotidine suppresses gastric secretion in cardiac surgery patients.
确定体外循环和法莫替丁对接受心脏手术的成年人胃酸分泌的影响。
前瞻性、随机、双盲、安慰剂对照研究。
大学教学医院。
18例接受体外循环择期心脏手术的患者。
麻醉诱导后及放置鼻胃pH探头后静脉注射法莫替丁20mg或0.9%氯化钠安慰剂。在重症监护病房术后12小时给予第二剂。体外循环后连续测量胃pH值，每4小时测量胃容量，最长24小时。
给予法莫替丁后，pH值在45分钟内升高43%，并在整个研究期间保持在5.5以上（与安慰剂和基线相比，p<0.05）。安慰剂组大多数患者在体外循环后长达12小时内胃pH值未升高，但仍保持在4.0以上。法莫替丁组胃容量平均降低24%（p>0.05）。
体外循环期间及体外循环后12小时胃酸分泌减少。围手术期给予法莫替丁可抑制心脏手术患者的胃分泌。
