Lian Q L, Hang R C, Yan H F, Chen T, Ni G T, Lu H Q, Liu Y Y, Liu X Q
Department of Diving Medicine, Naval Medical Faculty, Second Military Medical University, Shanghai, China.
Undersea Hyperb Med. 1995 Jun;22(2):153-60.
The contents of oxygen free radicals (OFRs) and malondialdehyde (MDA) in S-180 sarcoma tissues were measured in four groups of mice: an untreated normoxic group, a normoxic hyperbaric group, a hyperbaric oxygen group, and an HBO group treated with superoxide dismutase (SOD). Measurements were done by electron resonance and spectrophotometry, and observations were made on the volume, weight, necrosis incidence rate of sarcoma tissues, and mortality in all groups. The OFR and MDA content in sarcoma tissues in the HBO group was significantly higher than those of the control groups (P < 0.001); necrosis incidence of sarcoma tissues and the survival rate of mice were higher; the time required for necrosis was shorter, and the volume and weight of sarcoma tissues were smaller and lighter than those of the control groups (P < 0.01). The results suggest that SOD cannot completely eliminate OFRs produced by hyperbaric exposure, although the role of HBO in producing more OFRs can be counterbalanced by SOD to a certain degree. Apparently HBO can check the growth rate of sarcoma and accelerate the necrosis of S-180 sarcoma cells.
将四组小鼠的S-180肉瘤组织中的氧自由基（OFRs）和丙二醛（MDA）含量进行了测定：未处理的常氧组、常氧高压组、高压氧组和用超氧化物歧化酶（SOD）处理的高压氧组。通过电子共振和分光光度法进行测量，并对所有组的肉瘤组织体积、重量、坏死发生率和死亡率进行观察。高压氧组肉瘤组织中的OFR和MDA含量显著高于对照组（P<0.001）；肉瘤组织坏死发生率和小鼠存活率更高；坏死所需时间更短，肉瘤组织的体积和重量比对照组更小、更轻（P<0.01）。结果表明，SOD不能完全消除高压暴露产生的OFRs，尽管高压氧产生更多OFRs的作用可在一定程度上被SOD抵消。显然，高压氧可抑制肉瘤的生长速度并加速S-180肉瘤细胞的坏死。
