Santos-Benitez H, Magariños-Ascone C M, Garcia-Austt E
Servicio de Neurocirugía, Clínica Rúber, Madrid, Spain.
Brain Res Bull. 1995;37(5):507-11. doi: 10.1016/0361-9230(95)00033-b.
Extracellular cell activity was recorded in the intermediate and posterior subdivisions of the nucleus basalis of Meynert (NBM) of awake monkeys to determine cell characteristics and the motor and sensory participation. Animals were trained to move a lever by elbow flexion-extensions to receive a reward. Cell activity was recorded when the animal was at rest and executing the task. The electromyogram of the upper limb, contralateral to the recording site, was recorded simultaneously with NBM neuron activity. The effect of visual, auditory, and tactile stimuli were also studied after performance of the learned task. A moderate number of cells responded to the reward (16%), while a higher percentage of them was associated with unexpected, unspecific stimuli (22%). Firing rates correlated positively with limb movement (30%). Visual (34%) and auditory (15%) responses were also found. No NBM cell responded to tactile stimulation. Considering these findings and the anatomical projections over the cortex, the NBM role ion complex integrative processes in discussed.
在清醒猴子的梅纳特基底核（NBM）的中间和后部亚区记录细胞外活动，以确定细胞特征以及运动和感觉参与情况。训练动物通过屈肘和伸肘来移动杠杆以获得奖励。在动物休息和执行任务时记录细胞活动。与记录部位对侧的上肢肌电图与NBM神经元活动同时记录。在完成学习任务后，还研究了视觉、听觉和触觉刺激的效果。适度数量的细胞对奖励有反应（16%），而更高比例的细胞与意外的、非特异性刺激有关（22%）。放电频率与肢体运动呈正相关（30%）。还发现了视觉（34%）和听觉（15%）反应。没有NBM细胞对触觉刺激有反应。考虑到这些发现以及在皮质上的解剖投射，讨论了NBM在复杂整合过程中的作用。
