Fábryová L, Cagán S
IV. interná klinika LFUK v Bratislave, Slovakia.
Bratisl Lek Listy. 1995 Jan;96(1):23-9.
Recent research suggests that reactive oxygen species (including free radicals) may be involved in the initiation and development of vascular complication in diabetics. Free radicals meet many of the criteria required for a role in the pathogenesis of diabetic vascular disease: they are present in tissues affected by the diabetic process, they have a direct toxic effect on tissues, under certain condition glucose molecules can induce free radicals production. Diabetes mellitus represents a state of increased oxidative stress which is based on evidence of increased peroxidation, glycoxidation and reduced antioxidant reserve. Glycative stress can be modified by reducing glycemia, maintaining good diabetic control, and identifying the patients in whom diabetes or impaired glucose tolerance has not been diagnosed. Strategies for reducing the oxidative stress may include the supplementation of antioxidant micronutrients (vitamins E and C, beta-carotene). At present the most appropriate dose, form, method and site of administration of antioxidants are not known. One interesting therapeutic approach for the future will be to make apo-B particles more resistant to oxidative modification or to reduce the prooxidant activity in general.
近期研究表明，活性氧物质（包括自由基）可能参与糖尿病患者血管并发症的发生和发展。自由基符合在糖尿病血管疾病发病机制中发挥作用所需的许多标准：它们存在于受糖尿病进程影响的组织中，对组织具有直接毒性作用，在某些情况下葡萄糖分子可诱导自由基产生。糖尿病代表一种氧化应激增加的状态，这基于过氧化、糖基化增加以及抗氧化储备减少的证据。通过降低血糖、维持良好的糖尿病控制以及识别尚未诊断出糖尿病或糖耐量受损的患者，可以改善糖基化应激。降低氧化应激的策略可能包括补充抗氧化微量营养素（维生素E、维生素C、β-胡萝卜素）。目前，尚不清楚抗氧化剂最合适的剂量、形式、方法和给药部位。未来一种有趣的治疗方法将是使载脂蛋白B颗粒更能抵抗氧化修饰，或者总体上降低促氧化活性。
