Eur J Vasc Endovasc Surg. 1995 Jul;10(1):23-30. doi: 10.1016/s1078-5884(05)80194-7.
To correlate B-mode ultrasound findings to carotid plaque histology.
European multicentre study (nine centres).
Clinical presentation and risk factors were recorded and preoperative ultrasound Duplex scanning with special emphasis on B-mode imaging studies was performed in 270 patients undergoing carotid endarterectomy. Perioperatively, macroscopic plaque features were evaluated and the removed specimens were analysed histologically for fibrous tissue, calcification and 'soft tissue' (primarily haemorrhage and lipid).
Males had more soft tissue than females (p = 0.0006), hypertensive patients less soft tissue than normotensive (p = 0.01) and patients with recent symptoms more soft tissue than patients with earlier symptoms (p = 0.004). There was no correlation between surface description on ultrasound images compared to the surface judged intraoperatively by the surgeon. Echogenicity on B-mode images was inversely related to soft tissue (p = 0.005) and calcification was directly related to echogenicity (p < 0.0001). Heterogeneous plaques contained more calcification than homogeneous (p = 0.003), however, there was no difference in content of soft tissue.
Ultrasound B-mode characteristics are related to the histological composition of carotid artery plaques and to patient's history. These results may imply that patients with distant symptoms may be regarded and treated as asymptomatic patients whereas asymptomatic patients with echolucent plaques should be considered for carotid endarterectomy.
将B型超声检查结果与颈动脉斑块组织学进行关联。
欧洲多中心研究（九个中心）。
记录临床表现和危险因素，并对270例行颈动脉内膜切除术的患者进行术前超声双功扫描，特别强调B型成像研究。术中评估宏观斑块特征，并对切除的标本进行组织学分析，以检测纤维组织、钙化和“软组织”（主要是出血和脂质）。
男性的软组织比女性多（p = 0.0006），高血压患者的软组织比血压正常者少（p = 0.01），近期有症状的患者比早期有症状的患者软组织多（p = 0.004）。超声图像上的表面描述与外科医生术中判断的表面之间无相关性。B型图像上的回声性与软组织呈负相关（p = 0.005），钙化与回声性呈正相关（p < 0.0001）。异质性斑块比同质性斑块含有更多钙化（p = 0.003），然而，软组织含量无差异。
超声B型特征与颈动脉斑块的组织学组成及患者病史相关。这些结果可能意味着，有远期症状的患者可被视为无症状患者并进行治疗，而具有无回声斑块的无症状患者应考虑行颈动脉内膜切除术。
