Grimshaw G M, Thompson J M
Centre for Health Service Studies, University of Warwick, Coventry, U.K.
Eur J Vasc Endovasc Surg. 1995 Jul;10(1):95-100. doi: 10.1016/s1078-5884(05)80204-7.
This study defines a protocol for monitoring the growth of small abdominal aortic aneurysms based on age-related abnormality thresholds, observed aortic growth patterns and the limits of precision of the measurement technique.
13000 men aged 60 - 75 years were invited to their GP's surgery for measurement of the maximum diameter of the infrarenal aorta. Seventy-six percent responded and measurement was possible in 97.1% of the respondents. The AP diameter of the aorta was measured according to a strict protocol, with a portable ultrasound scanner.
Cases were recruited from the conurbation of Birmingham and Solihull, U.K. CHIEF OUTCOME MEASURE: A statistical description of the differences in distributions of aortic diameters of four age groups of males.
The aorta expands in diameter during the seventh and eighth decade for up to 25% of all those screened. The order of magnitude of this change is similar to that previously attributed to the growth of small aneurysms. Age-related thresholds for abnormality should range from 24 mm for a 60 year old to 37 mm for a 75 year old.
Using data on the expected maximum rate of change of the dilated aorta and statistically derived thresholds from this analysis a monitoring strategy is suggested for those with an abnormal aorta.
本研究基于年龄相关异常阈值、观察到的主动脉生长模式以及测量技术的精度限制，定义了一种监测小腹主动脉瘤生长的方案。
邀请13000名年龄在60 - 75岁的男性到其全科医生诊所测量肾下腹主动脉的最大直径。76%的人做出回应，97.1%的回应者能够进行测量。使用便携式超声扫描仪按照严格方案测量主动脉的前后径。
病例来自英国伯明翰和索利哈尔的市区。主要观察指标：对四个年龄组男性主动脉直径分布差异的统计描述。
在所有接受筛查的人中，高达25%的人在七十多岁和八十多岁时主动脉直径会扩大。这种变化的数量级与先前归因于小动脉瘤生长的数量级相似。与年龄相关的异常阈值范围应为60岁者24毫米至75岁者37毫米。
利用扩张主动脉预期最大变化率的数据以及本次分析统计得出的阈值，为主动脉异常者建议了一种监测策略。
