Ramsing D W, Agner T
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
Contact Dermatitis. 1995 May;32(5):293-7. doi: 10.1111/j.1600-0536.1995.tb00784.x.
Topical corticosteroids are frequently used in the treatment of irritant contact dermatitis (ICD). The efficacy of this treatment has, however, not been thoroughly established, and experimental studies on the topic have provided conflicting results. The aim of the present study was to evaluate the effect of potent topical corticosteroids on experimentally-induced irritant skin reactions in a double-blind, vehicle-controlled study. 16 healthy volunteers had sodium lauryl sulfate patch tests symmetrically applied to the upper arms. After removal of patch tests, a potent topical corticosteroid (betamethasone-17-valerate) was applied to the irritant skin reaction on one arm, while the corresponding vehicle was applied to the irritant skin reaction on the opposite arm 2x daily for 7 days. Reactions were evaluated by measurement of transepidermal water loss (TEWL) and erythema. After 7 days, statistically significant lower values of TEWL and erythema were found in corticosteroid-treated, compared to the vehicle-treated, skin reactions. The results indicate that topical corticosteroids improve healing of ICD.
外用皮质类固醇常用于治疗刺激性接触性皮炎（ICD）。然而，这种治疗方法的疗效尚未得到充分证实，关于该主题的实验研究结果相互矛盾。本研究的目的是在一项双盲、赋形剂对照研究中评估强效外用皮质类固醇对实验诱导的刺激性皮肤反应的影响。16名健康志愿者在上臂对称进行月桂醇硫酸酯钠斑贴试验。去除斑贴试验后，在一侧手臂的刺激性皮肤反应处涂抹一种强效外用皮质类固醇（倍他米松-17-戊酸酯），而在另一侧手臂的刺激性皮肤反应处涂抹相应的赋形剂，每天2次，共7天。通过测量经表皮水分流失（TEWL）和红斑来评估反应。7天后，与赋形剂治疗的皮肤反应相比，皮质类固醇治疗的皮肤反应中TEWL和红斑的值在统计学上显著更低。结果表明外用皮质类固醇可改善ICD的愈合。
