Orkin S H
Division of Hematology-Oncology, Children's Hospital, Boston, MA 02115, USA.
Eur J Biochem. 1995 Jul 15;231(2):271-81. doi: 10.1111/j.1432-1033.1995.tb20697.x.
Study of globin gene regulation has served as a useful paradigm for cell-specific and developmental control of transcription in higher eukaryotic cells. Recent work directed toward the identification and characterization of the cis-regulatory elements and transcription factors important for both aspects of control is reviewed. Particular emphasis is placed on the organization and function of globin locus control regions, mechanisms of switching of globin gene expression during development, and functions of the major erythroid-specific nuclear regulatory proteins.
珠蛋白基因调控的研究已成为高等真核细胞中转录的细胞特异性和发育调控的有用范例。本文综述了近期针对鉴定和表征对这两方面调控都很重要的顺式调控元件和转录因子的研究工作。特别强调了珠蛋白基因座控制区的组织和功能、发育过程中珠蛋白基因表达转换的机制以及主要红系特异性核调节蛋白的功能。
