长期摄入苯丁酸氮芥用于治疗卵巢癌。

Prolonged intake of chlorambucil for ovarian cancer.

作者信息

Khalil A M, Khatib R A, Shamseddine A I, Sharara N H, Seoud M A

机构信息

Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Lebanon.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1995 May;60(1):85-6. doi: 10.1016/0028-2243(94)02018-3.

DOI:10.1016/0028-2243(94)02018-3

PMID:7635238

Abstract

The use of alkylating agents has been reported to be a cause of secondary leukemia particularly in patients surviving for 2 years or more after treatment of ovarian carcinoma. The risk of developing leukemia is possibly related to the duration of treatment and the total dose of alkylating agents administered. We report a patient with epithelial ovarian carcinoma who received chlorambucil for 130 consecutive months with no clinical or laboratory evidence of leukemia.

摘要

据报道，使用烷化剂是继发性白血病的一个病因，尤其是在卵巢癌治疗后存活2年或更长时间的患者中。患白血病的风险可能与治疗持续时间和所给予的烷化剂总剂量有关。我们报告一例上皮性卵巢癌患者，其连续130个月接受苯丁酸氮芥治疗，无白血病的临床或实验室证据。