锂对大鼠腮腺和颌下腺功能的影响。

Effects of lithium on rat parotid and submandibulary gland functions.

Dehpour A R, Abdollahi M, Alghasi H

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran.

Gen Pharmacol. 1995 Jul;26(4):851-4. doi: 10.1016/0306-3623(94)00248-l.

Abstract

Pure submandibular and parotid saliva were collected intraorally by micro polyethylene canula from anesthetized lithium treated and control rats using pilocarpine as secretagogue. 2. Acute intraperitoneal injection of a single dose of lithium chloride (10 mg/kg), caused a significant decrease in protein, calcium, potassium and sodium concentrations of parotid saliva and also a significant decrease in protein, potassium and calcium concentrations of submandibular saliva. 3. Chronic treatment of rats for 10 days by LiCl solution (1200 mg/l) also caused some marked changes in saliva compositions similar to those observed in acute experiment. 4. The results of this study suggest that lithium as a drug used in the treatment of affective disorders can influence the secretory mechanisms of both submandibular and parotid glands. 5. These effects of lithium in composition of parotid and submandibular saliva are not related to duration of treatment.

摘要

通过微型聚乙烯插管经口腔从麻醉的锂处理大鼠和对照大鼠体内收集纯颌下腺和腮腺唾液，使用毛果芸香碱作为促分泌剂。2. 急性腹腔注射单剂量氯化锂（10毫克/千克）导致腮腺唾液中蛋白质、钙、钾和钠浓度显著降低，颌下腺唾液中蛋白质、钾和钙浓度也显著降低。3. 用LiCl溶液（1200毫克/升）对大鼠进行为期10天的慢性处理也导致唾液成分出现一些明显变化，类似于急性实验中观察到的变化。4. 本研究结果表明，锂作为用于治疗情感障碍的药物可影响颌下腺和腮腺的分泌机制。5. 锂对腮腺和颌下腺唾液成分的这些影响与治疗持续时间无关。