Hand I
Psychiatrische und Nervenklinik, Universitäts-Krankenhauses Eppendorf, Hamburg.
Fortschr Neurol Psychiatr. 1995 Jun;63 Suppl 1:12-8.
The term Obsessive Compulsive Disorder (OCD) is a label for a variety of syndromes with changing symptom configurations and different intraindividual as well as interactional functions. They are among the most difficult to treat psychiatric disorders. Heterogeneous variables affecting personal development in family, school, and peer-group, as well as genetic or brain organic variables contribute to the development of obsessions and compulsions. In more than 50% of patients with OCD we find one or more of the following disturbances before the outbreak of the disorder: low self-esteem; social deficits; increased anxiety level with increased, latent aggressiveness; striving for 100% security. Behaviour therapy today is the "treatment of choice" for OCD--both in respect of direct symptom reduction as well as the treatment of "causes", co-morbidity and risk factors. Additionally to the use of highly standardised "symptom techniques" individualized, multimodal treatment is necessary in the more severely disturbed patients. Long-term follow-up results show 50-80% success--probably depending on variations in the study samples regarding the type of obsessions and compulsions, the degree of developmental deficits before the occurrence of OCD, actual co-morbidity, and professional as well as private life conditions. Whether and to what degree additional psychotropic medication can enhance the efficacy of behaviour therapy, and whether the high relapse rates of 70% after discontinuation of previously successful drug treatment can be reduced by concomitant or subsequent behaviour therapy, cannot be safely concluded from the currently available studies. Are the non-responders in each of these treatments the responders of the non-responders in the alternative treatment mode?
强迫症(OCD)这一术语用于指代多种综合征,其症状构成不断变化,个体内部功能及人际互动功能也各不相同。它们是最难治疗的精神疾病之一。影响家庭、学校和同龄群体中个人发展的异质性变量,以及基因或大脑器质性变量,都促使强迫观念和强迫行为的形成。在超过50%的强迫症患者中,我们会在疾病发作前发现以下一种或多种紊乱情况:自卑;社交缺陷;焦虑水平升高且潜在攻击性增强;追求百分百的安全感。如今,行为疗法是强迫症的“首选治疗方法”——无论是在直接减轻症状方面,还是在治疗“病因”、共病及风险因素方面。除了使用高度标准化的“症状技术”外,对于病情更严重的患者,还需要进行个体化的多模式治疗。长期随访结果显示成功率为50% - 80%——这可能取决于研究样本在强迫观念和强迫行为类型、强迫症发作前发育缺陷程度、实际共病情况以及职业和私人生活状况等方面的差异。目前的研究尚无法确定额外的精神药物是否以及在何种程度上能提高行为疗法的疗效,也无法确定在先前成功的药物治疗停药后高达70%的高复发率是否能通过同时或后续的行为疗法降低。这些治疗中的无反应者是否就是另一种治疗模式中有反应者的无反应者呢?