Parent S, Bresler L, Tortuyaux J M, Boissel P
Service de Chirurgie C, CHU de Nancy, Vandoeuvre-Les-Nancy.
J Chir (Paris). 1995 Apr;132(4):171-7.
Crohn's disease needs medical and surgical management. Most patients are operated and surgical procedure the most often realised is intestinal resection. The authors report their experience of 106 intestinal resection performed between 01/01/1980 and 31/12/1992, in the "service de Chirurgie C" of the "CHU de Nancy" for patients operated for the first time for Crohn's disease. They were 54 men and 52 women with an average age of 31.7 years at operative time. The following clinical patterns were established: small intestine 36, colonic 10 and ileocolic 60 patients. The average length of evolution before surgery was 4.5 years. The main indication was intestinal obstruction in small intestine patterns (91%) and poor response to medical therapy in colonic patterns (30%). Usual surgical procedure was to remove all visibly diseased bowell with healthy margin of resection, as judged by gross examination, of 3 to 5 cm. Postoperative morbidity was low (17.9%) with 3 anastomotic leakages. Postoperative morbidity was 1.9% (2 patients). The average duration of follow-up was 4 years. Among the 106 patients operated for the first time for their Crohn's disease, 19 (18%) were operated again, at least one time, during the follow-up. The quality of life of operated patients is considered as good with only one patient very invalidated by a short small bowel syndrome. According to the data of their series and the literature, the authors conclude that in Crohn's disease, excisional surgery is able to improve patients clinical status account to a low morbidity and mortality, with a low risk of short small bowel syndrome as clinical course but it does not avoid recurrence.
克罗恩病需要药物和手术治疗。大多数患者接受手术治疗,最常实施的手术是肠切除术。作者报告了他们在1980年1月1日至1992年12月31日期间,在南锡大学医院“C外科”为首次因克罗恩病接受手术的患者进行106例肠切除术的经验。患者中男性54例,女性52例,手术时平均年龄为31.7岁。确立了以下临床类型:小肠型36例,结肠型10例,回结肠型60例。手术前的平均病程为4.5年。主要指征在小肠型中是肠梗阻(91%),在结肠型中是对药物治疗反应不佳(30%)。常规手术是切除所有肉眼可见病变的肠段,并根据大体检查判断,切除边缘健康组织3至5厘米。术后发病率较低(17.9%),有3例吻合口漏。术后死亡率为1.9%(2例患者)。平均随访时间为4年。在106例首次因克罗恩病接受手术的患者中,19例(18%)在随访期间至少再次接受了一次手术。手术患者的生活质量被认为良好,只有1例患者因短肠综合征而严重致残。根据他们系列研究的数据和文献,作者得出结论,在克罗恩病中,切除手术能够改善患者的临床状况,因为发病率和死亡率较低,作为临床病程,短肠综合征风险较低,但不能避免复发。