Giard C, Asselain B, Clough K B, Renolleau C, Durand J C
Institut Curie, Section médicale et hospitalière, Paris.
J Chir (Paris). 1995 Apr;132(4):186-90.
From 1960 to 1989, 154 cases of recurrent breast cancer after conservative radiosurgery were treated at the Curie Institute. Relapse was discovered at clinical examination in 88% of the cases and mammography was only useful in 45%. In 18 cases (12%) an unpalpable tumour was discovered at mammography, especially for intragalactophoric tumors. Cytopuncture yielded a precise diagnosis in 83% of the cases. Overall survival rate after recurrence was 72% at 5 years (62% without metastasis). Survival rate was better for late recurrence, and poorer in cases with subclinical axillary invasion. Neither age nor type of treatment had any effect on survival. Indications for general associated treatment are based on: the invasive character of the recurrent tumour, axillary invasion, tumour size and delay to recurrence after initial surgery.
1960年至1989年期间,居里研究所对154例保守性放射治疗后复发的乳腺癌患者进行了治疗。88%的病例是在临床检查时发现复发的,乳腺X线摄影仅在45%的病例中有用。在18例(12%)病例中,乳腺X线摄影发现了触诊不到的肿瘤,尤其是乳管内肿瘤。细胞穿刺在83%的病例中给出了准确诊断。复发后的5年总生存率为72%(无转移者为62%)。晚期复发患者的生存率较高,有亚临床腋窝侵犯的患者生存率较低。年龄和治疗类型对生存率均无影响。综合相关治疗的指征基于:复发性肿瘤的浸润性、腋窝侵犯、肿瘤大小以及初次手术后复发的时间。