• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

牛乳头瘤病毒无法通过靶向破坏胰岛素样生长因子I受体基因来转化小鼠胚胎成纤维细胞。

Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes.

作者信息

Morrione A, DeAngelis T, Baserga R

机构信息

Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

出版信息

J Virol. 1995 Sep;69(9):5300-3. doi: 10.1128/JVI.69.9.5300-5303.1995.

DOI:10.1128/JVI.69.9.5300-5303.1995
PMID:7636972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189367/
Abstract

Mouse embryo cells with a targeted disruption of the insulin-like growth factor I receptor (IGF-IR) genes (R- cells) are refractory to transformation by the simian virus 40 large T antigen and/or an activated and overexpressed Ras, both of which readily transform cells from wild-type littermate embryos and other 3T3-like cells. R- cells are also refractory to transformation induced by overexpressed epidermal growth factor receptor and platelet-derived growth factor receptor beta. Since the platelet-derived growth factor receptor beta is required for transformation by bovine papillomavirus, we inquired whether the IGF-IR was also required for transformation by bovine papillomavirus E5 oncoprotein. We show here that R- cells are refractory to transformation by E5; reintroduction into R- cells of a human IGF-IR restores the susceptibility to transformation.

摘要

胰岛素样生长因子I受体（IGF-IR）基因发生靶向破坏的小鼠胚胎细胞（R-细胞）对猿猴病毒40大T抗原和/或激活并过度表达的Ras介导的转化具有抗性，而这两者都能轻易地转化来自野生型同窝胚胎的细胞以及其他3T3样细胞。R-细胞对过度表达的表皮生长因子受体和血小板衍生生长因子受体β诱导的转化也具有抗性。由于血小板衍生生长因子受体β是牛乳头瘤病毒转化所必需的，我们探究了IGF-IR是否也是牛乳头瘤病毒E5癌蛋白转化所必需的。我们在此表明，R-细胞对E5介导 的转化具有抗性；将人IGF-IR重新导入R-细胞可恢复其对转化的敏感性。

相似文献

1
Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes.牛乳头瘤病毒无法通过靶向破坏胰岛素样生长因子I受体基因来转化小鼠胚胎成纤维细胞。
J Virol. 1995 Sep;69(9):5300-3. doi: 10.1128/JVI.69.9.5300-5303.1995.
2
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.胰岛素样生长因子I受体基因无效突变对小鼠胚胎成纤维细胞生长和转化的影响。
Mol Cell Biol. 1994 Jun;14(6):3604-12. doi: 10.1128/mcb.14.6.3604-3612.1994.
3
Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor.胰岛素样生长因子I受体是血小板衍生生长因子受体的促有丝分裂和转化活性所必需的。
J Cell Physiol. 1995 Jul;164(1):214-21. doi: 10.1002/jcp.1041640126.
4
Stabilization of the Ras oncoprotein by the insulin-like growth factor 1 receptor during anchorage-independent growth.
Cancer Res. 2000 Aug 1;60(15):4222-30.
5
Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor.通过胰岛素样生长因子-I受体C末端截短实现有丝分裂原作用与转化活性的解离
Exp Cell Res. 1995 May;218(1):370-80. doi: 10.1006/excr.1995.1168.
6
Transformation-specific interaction of the bovine papillomavirus E5 oncoprotein with the platelet-derived growth factor receptor transmembrane domain and the epidermal growth factor receptor cytoplasmic domain.牛乳头瘤病毒E5癌蛋白与血小板衍生生长因子受体跨膜结构域及表皮生长因子受体胞质结构域的转化特异性相互作用。
J Virol. 1993 Sep;67(9):5303-11. doi: 10.1128/JVI.67.9.5303-5311.1993.
7
Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells.胰岛素样生长因子I受体酪氨酸950位点突变对细胞生长和转化的影响。
Cancer Res. 1995 Feb 1;55(3):663-7.
8
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.猿猴病毒40大T抗原无法转化缺乏1型胰岛素样生长因子受体的小鼠胚胎成纤维细胞。
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11217-21. doi: 10.1073/pnas.90.23.11217.
9
Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.牛乳头瘤病毒E5转化蛋白与小鼠C127细胞中血小板衍生生长因子内源性β受体之间相互作用的突变分析。
J Virol. 1995 Sep;69(9):5869-74. doi: 10.1128/JVI.69.9.5869-5874.1995.
10
The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.人胰岛素样生长因子（IGF）结合蛋白-3通过对IGF-I受体基因的靶向破坏来抑制成纤维细胞的生长。
Mol Endocrinol. 1995 Mar;9(3):361-7. doi: 10.1210/mend.9.3.7539889.

引用本文的文献

1
The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities.IGF1 信号通路：从基础概念到治疗机会。
Int J Mol Sci. 2023 Oct 4;24(19):14882. doi: 10.3390/ijms241914882.
2
Novel Regulators of the IGF System in Cancer.癌症中 IGF 系统的新型调节因子
Biomolecules. 2021 Feb 12;11(2):273. doi: 10.3390/biom11020273.
3
MicroRNA-497 regulates cell proliferation in hepatocellular carcinoma.微小RNA-497调节肝细胞癌中的细胞增殖。
Oncol Lett. 2016 Feb;11(2):1081-1088. doi: 10.3892/ol.2015.3981. Epub 2015 Dec 1.
4
The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma.转录因子Ik-1和MZF1下调NPM-ALK⁺ T细胞淋巴瘤中IGF-IR的表达。
Mol Cancer. 2015 Feb 25;14:53. doi: 10.1186/s12943-015-0324-2.
5
The insulin and igf-I pathway in endocrine glands carcinogenesis.内分泌腺肿瘤发生过程中的胰岛素和 IGF-I 通路。
J Oncol. 2012;2012:635614. doi: 10.1155/2012/635614. Epub 2012 Aug 8.
6
Gene expression analysis of pancreatic cystic neoplasm in SV40Tag transgenic mice model.SV40Tag转基因小鼠模型中胰腺囊性肿瘤的基因表达分析
World J Gastroenterol. 2007 Apr 21;13(15):2218-22. doi: 10.3748/wjg.v13.i15.2218.
7
A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer.胰岛素样生长因子I受体的高表达水平与转录因子Sp1的表达增加及人胃癌区域淋巴结转移相关。
Clin Exp Metastasis. 2004;21(8):755-64. doi: 10.1007/s10585-005-1198-2.
8
Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells.C/EBPβ和胰岛素样生长因子I在巨噬细胞肿瘤细胞中的关键促存活作用。
Mol Cell Biol. 2004 Apr;24(8):3238-50. doi: 10.1128/MCB.24.8.3238-3250.2004.
9
IGF-I receptor signalling in transformation and differentiation.胰岛素样生长因子-I受体信号传导在细胞转化与分化中的作用
Mol Pathol. 2001 Jun;54(3):133-7. doi: 10.1136/mp.54.3.133.
10
Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation.蛋白激酶C-δ是胰岛素样生长因子I受体介导的细胞转化中的重要信号分子。
Mol Cell Biol. 1998 Oct;18(10):5888-98. doi: 10.1128/MCB.18.10.5888.

本文引用的文献

1
The role of the IGF-I receptor in the growth and transformation of mammalian cells.胰岛素样生长因子-I受体在哺乳动物细胞生长与转化中的作用。
Cell Prolif. 1994 Feb;27(2):63-71. doi: 10.1111/j.1365-2184.1994.tb01406.x.
2
Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.通过表达反义胰岛素样生长因子I RNA的免疫原性C6细胞治疗和预防大鼠胶质母细胞瘤
Science. 1993 Jan 1;259(5091):94-7. doi: 10.1126/science.8418502.
3
Role of insulin-like growth factors in embryonic and postnatal growth.胰岛素样生长因子在胚胎及出生后生长中的作用。
Cell. 1993 Oct 8;75(1):73-82.
4
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).携带编码胰岛素样生长因子I（Igf-1）和1型IGF受体（Igf1r）基因无效突变的小鼠。
Cell. 1993 Oct 8;75(1):59-72.
5
Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein.血小板衍生生长因子受体可介导牛乳头瘤病毒E5蛋白的致瘤转化。
Mol Cell Biol. 1993 Jul;13(7):4137-45. doi: 10.1128/mcb.13.7.4137-4145.1993.
6
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.猿猴病毒40大T抗原无法转化缺乏1型胰岛素样生长因子受体的小鼠胚胎成纤维细胞。
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11217-21. doi: 10.1073/pnas.90.23.11217.
7
Cellular transformation by a transmembrane peptide: structural requirements for the bovine papillomavirus E5 oncoprotein.跨膜肽介导的细胞转化：牛乳头瘤病毒E5癌蛋白的结构要求
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4634-8. doi: 10.1073/pnas.91.11.4634.
8
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.胰岛素样生长因子I受体基因无效突变对小鼠胚胎成纤维细胞生长和转化的影响。
Mol Cell Biol. 1994 Jun;14(6):3604-12. doi: 10.1128/mcb.14.6.3604-3612.1994.
9
Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cells.牛乳头瘤病毒E5转化蛋白与血小板衍生生长因子β受体在稳定转化和急性转染细胞中的特异性相互作用。
J Virol. 1994 Jun;68(6):3582-92. doi: 10.1128/JVI.68.6.3582-3592.1994.
10
Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.表达胰岛素样生长因子-1（IGF-1）受体反义RNA的大鼠胶质母细胞瘤细胞无致瘤性，并可诱导野生型肿瘤消退。
Cancer Res. 1994 Apr 15;54(8):2218-22.