牛乳头瘤病毒无法通过靶向破坏胰岛素样生长因子I受体基因来转化小鼠胚胎成纤维细胞。
Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes.
作者信息
Morrione A, DeAngelis T, Baserga R
机构信息
Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
出版信息
J Virol. 1995 Sep;69(9):5300-3. doi: 10.1128/JVI.69.9.5300-5303.1995.
Abstract
Mouse embryo cells with a targeted disruption of the insulin-like growth factor I receptor (IGF-IR) genes (R- cells) are refractory to transformation by the simian virus 40 large T antigen and/or an activated and overexpressed Ras, both of which readily transform cells from wild-type littermate embryos and other 3T3-like cells. R- cells are also refractory to transformation induced by overexpressed epidermal growth factor receptor and platelet-derived growth factor receptor beta. Since the platelet-derived growth factor receptor beta is required for transformation by bovine papillomavirus, we inquired whether the IGF-IR was also required for transformation by bovine papillomavirus E5 oncoprotein. We show here that R- cells are refractory to transformation by E5; reintroduction into R- cells of a human IGF-IR restores the susceptibility to transformation.
摘要
胰岛素样生长因子I受体（IGF-IR）基因发生靶向破坏的小鼠胚胎细胞（R-细胞）对猿猴病毒40大T抗原和/或激活并过度表达的Ras介导的转化具有抗性，而这两者都能轻易地转化来自野生型同窝胚胎的细胞以及其他3T3样细胞。R-细胞对过度表达的表皮生长因子受体和血小板衍生生长因子受体β诱导的转化也具有抗性。由于血小板衍生生长因子受体β是牛乳头瘤病毒转化所必需的，我们探究了IGF-IR是否也是牛乳头瘤病毒E5癌蛋白转化所必需的。我们在此表明，R-细胞对E5介导 的转化具有抗性；将人IGF-IR重新导入R-细胞可恢复其对转化的敏感性。
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本文引用的文献
1
The role of the IGF-I receptor in the growth and transformation of mammalian cells.
Cell Prolif. 1994 Feb;27(2):63-71. doi: 10.1111/j.1365-2184.1994.tb01406.x.
2
Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.
Science. 1993 Jan 1;259(5091):94-7. doi: 10.1126/science.8418502.
3
Role of insulin-like growth factors in embryonic and postnatal growth.
Cell. 1993 Oct 8;75(1):73-82.
4
5
Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein.
Mol Cell Biol. 1993 Jul;13(7):4137-45. doi: 10.1128/mcb.13.7.4137-4145.1993.
6
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11217-21. doi: 10.1073/pnas.90.23.11217.
7
Cellular transformation by a transmembrane peptide: structural requirements for the bovine papillomavirus E5 oncoprotein.
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4634-8. doi: 10.1073/pnas.91.11.4634.
8
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.
Mol Cell Biol. 1994 Jun;14(6):3604-12. doi: 10.1128/mcb.14.6.3604-3612.1994.
9
Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cells.
J Virol. 1994 Jun;68(6):3582-92. doi: 10.1128/JVI.68.6.3582-3592.1994.
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