Shukla P C, Chaube D K
Department of Chemistry, St. Andrew's Post Graduate College, Gorakhpur, U.P., India.
J Urol. 1995 Sep;154(3):990-5.
We ascertain the role of urea in urine and its probable effects on the polarizable behavior of bladder interfaces.
Urine was systematically diluted, keeping overall volume the same. The methodology of nonequilibrium thermodynamics was used, which involves measurements of hydrodynamic permeability, electro-osmotic permeability, streaming potential and streaming currents, respectively.
Effective pressure terms (alpha 1) and polarizability terms (alpha 2) were computed, making use of higher order phenomenological coefficients, and their concentration dependence was examined. Abrupt changes in the values of alpha 1 and alpha 2 are supported by trends in higher order phenomenological coefficients.
The polarizable behavior of the bladder is maintained up to certain concentrations of urea in urine and then it undergoes drastic changes. The role of the bladder in situations of improper functioning of the liver and diets without protein may provide an explanation.
我们确定尿液中尿素的作用及其对膀胱界面极化行为可能产生的影响。
系统稀释尿液，保持总体积不变。采用非平衡热力学方法，分别测量流体动力渗透率、电渗渗透率、流动电位和流动电流。
利用高阶唯象系数计算有效压力项（α1）和极化率项（α2），并研究它们的浓度依赖性。α1和α2值的突然变化得到高阶唯象系数趋势的支持。
膀胱的极化行为在尿液中尿素达到一定浓度之前得以维持，之后则会发生剧烈变化。肝脏功能异常和无蛋白饮食情况下膀胱的作用可能对此做出解释。
