[柔红霉素诱导的肾病大鼠中乳糜微粒和极低密度脂蛋白的代谢]

[Chylomicron and VLDL metabolism in daunomycin-induced nephrotic rats].

作者信息

Gomikawa S, Hiraoka K, Yamanashi T, Mori H, Fujita Y, Takamitsu Y

机构信息

Renal Unit, Hyogo College of Medicine, Nishinomiya, Japan.

出版信息

Nihon Jinzo Gakkai Shi. 1995 Jul;37(7):366-72.

PMID:7637207

Abstract

Lipid metabolism in chylomicron and VLDL were examined in daunomycin-induced nephrotic rats. 1) There was no difference in intestinal cholesterogenesis between the control rats and daunomycin-induced nephrotic rats. 2) The apoprotein content of chylomicron and VLDL increased in daunomycin-induced nephrotic rats. 3) Daunomycin-induced nephrotic rats showed increases in the content of apo B-48 and C-III, and a decrease in that of apo E in chylomicron. The apoprotein composition of VLDL in daunomycin-induced nephrotic rats showed increased apo B and decreased apo E. These results suggest that increased chylomicron-cholesterol is not due to increased intestinal cholesterogenesis, but to decreased chylomicron catabolism in daunomycin-induced nephrotic rats. Increased apoprotein in VLDL may contribute to the decreased catabolism by reducing LPL activity in the plasma and increased secretion from the liver of daunomycin induced nephrotic rats.

摘要

在柔红霉素诱导的肾病大鼠中检测了乳糜微粒和极低密度脂蛋白（VLDL）中的脂质代谢。1）对照大鼠和柔红霉素诱导的肾病大鼠在肠道胆固醇生成方面没有差异。2）柔红霉素诱导的肾病大鼠中乳糜微粒和VLDL的载脂蛋白含量增加。3）柔红霉素诱导的肾病大鼠乳糜微粒中载脂蛋白B - 48和C - III的含量增加，而载脂蛋白E的含量降低。柔红霉素诱导的肾病大鼠中VLDL的载脂蛋白组成显示载脂蛋白B增加而载脂蛋白E减少。这些结果表明，柔红霉素诱导的肾病大鼠中乳糜微粒胆固醇增加并非由于肠道胆固醇生成增加，而是由于乳糜微粒分解代谢减少。VLDL中载脂蛋白增加可能通过降低血浆中脂蛋白脂肪酶（LPL）活性以及柔红霉素诱导的肾病大鼠肝脏分泌增加而导致分解代谢降低。