Tashiro K, Nakajo H, Iwamuro S, Furuta A, Iwanaga S, Ohishi Y, Igarashi H, Kawashima A, Sugiyama K, Kido A
Department of Urology, Atsugi Prefectural Hospital.
Nihon Hinyokika Gakkai Zasshi. 1995 Jul;86(7):1272-8. doi: 10.5980/jpnjurol1989.86.1272.
A total of 205 patients with primary superficial bladder cancer (Ta, T1) followed more than 3 years were retrospectively analyzed for factors related to recurrence of tumors after transurethral resection. Patients age were 25 to 90 years old, average 61 years old, and there were 160 males and 45 females. Initial tumor grades were G0 in 4 patients, G1 in 48, G2 in 134 and G3 in 19. Seventy four patients had Ta tumor and 131 had T1. Initial treatments were transurethral resection (TUR) alone in 137 patients. TUR with intravesical chemotherapy in 64, with BCG therapy in 7 and others in 7. Factors examined included age, sex, chief complaint, shape, size, and number of tumors, tumor distribution (single area or multiple area), histological grade, stage and intravesical chemotherapy. Overall non-recurrent rate were 81.7% at 1 year, 60.7% at 3 year, 53. 8% at 5 year and 44.2% at 8 year. Five-year non-recurrent rate according tumor factors, showed significant difference regarding tumor size (< 1 cm or 1 cm <: P = 0.027), tumor number (single or multiple: P = 0.004), tumor distribution (single area or multiple area: p = 0.002), histological grade (< G1 or G2 < : p = 0.001) and stage (Ta or T1: p = 0001). However, there were no significant difference regarding factors of age, sex, chief complaint, tumor figure and presence or absence of intravesical chemotherapy. This results suggested that the tumor factors of size, number, tumor distribution, grade and stage were highly related to intravesical tumor recurrence of superficial bladder cancer.
对205例原发性浅表性膀胱癌（Ta、T1期）且随访超过3年的患者进行回顾性分析，以探讨经尿道切除术后肿瘤复发的相关因素。患者年龄为25至90岁，平均61岁，其中男性160例，女性45例。初始肿瘤分级：G0级4例，G1级48例，G2级134例，G3级19例。Ta期肿瘤74例，T1期肿瘤131例。初始治疗：137例患者仅行经尿道切除术（TUR）；64例行TUR联合膀胱内化疗；7例行TUR联合卡介苗治疗；7例为其他治疗。研究因素包括年龄、性别、主诉、肿瘤形状、大小、数量、肿瘤分布（单区域或多区域）、组织学分级、分期及膀胱内化疗。1年时总体无复发率为81.7%，3年时为60.7%，5年时为53.8%，8年时为44.2%。根据肿瘤因素得出的5年无复发率在肿瘤大小（<1 cm或≥1 cm：P = 0.027）、肿瘤数量（单发或多发：P = 0.004）、肿瘤分布（单区域或多区域：P = 0.002）、组织学分级（<G1或≥G2：P = 0.001）及分期（Ta或T1：P = 0.001）方面显示出显著差异。然而，在年龄、性别、主诉、肿瘤形态及是否进行膀胱内化疗等因素方面无显著差异。该结果表明，肿瘤的大小、数量、分布、分级及分期等因素与浅表性膀胱癌的膀胱内肿瘤复发高度相关。
