Millikan K W, Silverstein J C, Timmerman G, Economou S G
Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.
J Surg Res. 1995 Aug;59(2):229-35. doi: 10.1006/jsre.1995.1159.
Fractionated radiation therapy after liver resection for metastatic cancer has traditionally been a palliative procedure. Here, we consider that radiation may be an appropriate adjuvant therapy for cure after liver resection for metastases. This pilot study in rats establishes a model for evaluating the effects of fractionated irradiation posthepatectomy. Sixty Sprague-Dawley rats were randomized to four groups. The groups underwent laparotomy, laparotomy and radiation, hepatectomy, and hepatectomy and radiation. We found that the rats treated with radiation had statistically significant (P < 0.0001) clinical radiation change by liver function tests at 6 months. This damage was resolved to normal at 1 year regardless of hepatectomy. In fact, we demonstrate the possibility of a protective effect from radiation damage in the regenerated liver. We also demonstrate statistically significant histologic change at 8 months (P < 0.01) in the radiation-treated rats which does not resolve at 1 year.
传统上，转移性癌症肝切除术后的分割放射治疗一直是一种姑息性治疗手段。在此，我们认为放射治疗可能是转移性癌症肝切除术后合适的辅助性治愈性疗法。这项大鼠实验性研究建立了一个用于评估肝切除术后分割照射效果的模型。60只斯普拉格-道利大鼠被随机分为四组。这些组分别接受剖腹术、剖腹术加放射治疗、肝切除术以及肝切除术加放射治疗。我们发现，接受放射治疗的大鼠在6个月时通过肝功能测试显示出具有统计学意义（P < 0.0001）的临床放射变化。无论是否进行肝切除术，这种损伤在1年时都恢复正常。事实上，我们证明了再生肝脏对放射损伤具有保护作用的可能性。我们还证明，接受放射治疗的大鼠在8个月时出现了具有统计学意义的组织学变化（P < 0.01），且这种变化在1年时并未恢复。
