Skrede S, Iversen P O
Institute of Medical Biochemistry, University of Oslo, Norway.
Leuk Res. 1995 Jul;19(7):463-7. doi: 10.1016/0145-2126(95)00002-6.
The metabolism of bone marrow cells during the development of acute promyelocytic leukaemia has only been scarcely characterized, even though such knowledge might improve our understanding of the mechanisms of leukemogenesis as well as of drug treatment failure. We have investigated the in vitro oxygen consumption and the metabolism of palmitate in rat bone marrow cells during development of acute promyelocytic leukaemia. As the leukaemia progressed, the cellular oxygen consumption, the beta-oxidation of palmitate and the incorporation of palmitate into phospholipids all increased markedly. Cyclophosphamide supplement led to a temporary reduction of the palmitate metabolism, but did not lower the increased oxygen consumption. We conclude that the cellular metabolic rate is elevated during the progression of acute promyelocytic leukaemia, and that this might reflect an enhanced proliferative rate of the malignant cells.
尽管了解急性早幼粒细胞白血病（APL）发生发展过程中骨髓细胞的代谢情况可能有助于我们更好地理解白血病的发病机制以及药物治疗失败的原因，但目前这方面的研究还很少。我们研究了大鼠骨髓细胞在APL发生发展过程中的体外氧消耗和棕榈酸代谢情况。随着白血病的进展，细胞氧消耗、棕榈酸的β氧化以及棕榈酸掺入磷脂的量均显著增加。补充环磷酰胺导致棕榈酸代谢暂时降低，但并未降低增加的氧消耗。我们得出结论，在APL进展过程中细胞代谢率升高，这可能反映了恶性细胞增殖率的提高。
