肾上腺紧张素：一种与肾上腺髓质素作用相反的肾上腺髓质素基因产物。
Adrenotensin: an ADM gene product with the opposite effects of ADM.
作者信息
Gumusel B, Chang J K, Hyman A, Lippton H
机构信息
Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
出版信息
Life Sci. 1995;57(8):PL87-90. doi: 10.1016/0024-3205(95)02012-8.
The purpose of the present study was to investigate the effects of putative products of the ADM gene, other than ADM including, prodepin, proADM45-92 and proADM153-185 on cat pulmonary arterial (PA) rings with or without precontraction with U46619. Addition of proADM153-185 (3 x 10(-10)-10(-6) M) increased tension in a concentration-dependent manner in cat PA rings without precontraction. When vessels were precontracted with U46619, ADM(3 x 10(-10)-10(-6) M) produced a concentration-dependent vasorelaxant response, whereas proADM153-185 produced a weak concentration-dependent contractile response. Prodepin and proADM45-92 up to 10(-6)M had no activity on PA rings. Since proADM153-185, similar to ADM, would be expected to be released in free form following endopeptidase-induced cleavage, the present data suggest proADM undergoes proteolytic processing to release peptides with divergent vascular effects. Thus, the present data also suggest that proADM153-185 may represent a novel product of the ADM gene and term this putative new substance "adrenotensin".
本研究的目的是研究除ADM（包括前降钙素原、proADM45 - 92和proADM153 - 185）外，ADM基因假定产物对预先用U46619预收缩或未预收缩的猫肺动脉（PA）环的影响。在未预收缩的猫PA环中，添加proADM153 - 185（3×10⁻¹⁰ - 10⁻⁶ M）可使张力呈浓度依赖性增加。当血管用U46619预收缩时，ADM（3×10⁻¹⁰ - 10⁻⁶ M）产生浓度依赖性血管舒张反应，而proADM153 - 185产生微弱的浓度依赖性收缩反应。高达10⁻⁶ M的前降钙素原和proADM45 - 92对PA环无活性。由于proADM153 - 185与ADM类似，预计在内肽酶诱导切割后会以游离形式释放，目前的数据表明proADM经过蛋白水解加工以释放具有不同血管作用的肽。因此，目前的数据还表明proADM153 - 185可能代表ADM基因的一种新产物，并将这种假定的新物质命名为“肾上腺紧张素”。
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