齿状回中长时程增强（LTP）递减性质的分析。
Analysis of the decremental nature of LTP in the dentate gyrus.
作者信息
Abraham W C, Mason-Parker S E, Williams J, Dragunow M
机构信息
Department of Psychology, University of Otago, Dunedin, New Zealand.
出版信息
Brain Res Mol Brain Res. 1995 Jun;30(2):367-72. doi: 10.1016/0169-328x(95)00026-o.
The persistence of long-term potentiation (LTP) in the dentate gyrus was compared for two tetanization protocols: 50 trains on one day, or 50 trains on 5 consecutive days. LTP induction was significantly greater in the 250 train condition, but the LTP decay rate over weeks was similar between conditions. The decay of LTP could not be accounted for by deterioration of the preparation. Successive days of stimulation caused repetitive induction of immediate early genes, but did not prolong LTP, suggesting that either the effects of gene expression on LTP stabilization had saturated, or that these genes play other roles in synaptic plasticity.
比较了两种强直刺激方案下齿状回长期增强（LTP）的持续性：一天进行50串刺激，或连续5天每天进行50串刺激。在250串刺激条件下，LTP诱导显著更强，但数周内两种条件下LTP的衰减率相似。LTP的衰减不能用标本的退化来解释。连续几天的刺激导致即刻早期基因的重复诱导，但并未延长LTP，这表明要么基因表达对LTP稳定的作用已经饱和，要么这些基因在突触可塑性中发挥其他作用。
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