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[从身心角度看痉挛性斜颈的亚组。144例病例的聚类分析结果。德国肌张力障碍研究小组]

[Subgroups of torticollis spasmodicus from the psychosomatic viewpoint. Results of a cluster analysis of 144 cases. German Study Group of Dystonia Research].

作者信息

Scheidt C E, Rayki O, Heinen F, Nickel T

机构信息

Abteilung Psychotherapie und Psychosomatik, Universität Freiburg.

出版信息

Nervenarzt. 1995 Jun;66(6):422-9.

PMID:7637828
Abstract

The question of subgroups in idiopathic spasmodic torticollis, which has been discussed in earlier studies in order to define etiologically heterogeneous patient populations has lost some of its relevance since with the injection of botulinum toxin an effective treatment is available. However, psychosocial distress is linked with spasmodic torticollis in a substantial number of patients. In order to define criteria for psychosocial interventions in addition to the treatment with botulinum toxin, a cluster analysis was carried out to identify high-risk populations in terms of psychological and social distress. Five subgroups were defined on the basis of eight variables. Two of these five groups, one group with rotational torticollis and one with laterocollis, emerged as particularly distressed by their physical complaints, the effects of their illness on various areas of life and in terms of psychological functioning. The consistency of the subgroups was tested and statistically confirmed by analysis of variance. In a cross-validation 83.02% of the ungrouped cases were predicted correctly. The authors suggest that the evaluation of psychological and social aspects of the condition should be part of the neurological assessment in order to offer appropriate support to patients, who reveal a high degree of psychological distress.

摘要

特发性痉挛性斜颈的亚组问题在早期研究中曾被讨论,目的是界定病因学上异质性的患者群体,但自从有了肉毒杆菌毒素注射这种有效治疗方法后,该问题的相关性已有所降低。然而,相当一部分患者的心理社会困扰与痉挛性斜颈有关。为了确定除肉毒杆菌毒素治疗外心理社会干预的标准,进行了聚类分析,以识别在心理和社会困扰方面的高危人群。基于八个变量定义了五个亚组。这五个组中的两组,一组为旋转性斜颈,一组为侧屈性斜颈,因其身体不适、疾病对生活各方面的影响以及心理功能方面而表现出特别的困扰。通过方差分析对亚组的一致性进行了检验并得到统计学确认。在交叉验证中,83.02%的未分组病例被正确预测。作者建议,对该病症心理和社会方面的评估应成为神经学评估的一部分,以便为表现出高度心理困扰的患者提供适当支持。

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