Náfrádi L, Varga L
Vas Megyei Markusovszky Kórház Rheumatológiai Osztály, Szombathely.
Orv Hetil. 1995 Jul 16;136(29):1555-7.
The clinical efficacy and the side effects of a long term (max. 42 months, min. 5 months) weekly pulse methotrexate treatment (10 mg/week) were investigated in 31 rheumatoid arthritis patients and in 14 with psoriatic arthritis. A reduction in the number of inflamed joints and diminished duration of morning stiffness could be observed together with a decrease of pain and of the erythrocyte sedimentation rate in rheumatoid arthritis. In patients with psoriatic arthritis the intensity of joint pain was not influenced considerable and the decrease of the erythrocyte sedimentation rate was not as great as in rheumatoid arthritis patients. Ineffectivity of the methotrexate treatment occurred in one rheumatoid arthritic patient. The methotrexate treatment could not be carried on in two rheumatoid arthritic patients because of adverse side effects.
对31例类风湿关节炎患者和14例银屑病关节炎患者进行了长期（最长42个月，最短5个月）每周一次脉冲式甲氨蝶呤治疗（10毫克/周）的临床疗效及副作用研究。在类风湿关节炎患者中，可观察到炎症关节数量减少、晨僵持续时间缩短，同时疼痛减轻、红细胞沉降率下降。在银屑病关节炎患者中，关节疼痛强度未受到显著影响，红细胞沉降率下降幅度不如类风湿关节炎患者大。1例类风湿关节炎患者甲氨蝶呤治疗无效。2例类风湿关节炎患者因不良反应无法继续进行甲氨蝶呤治疗。
