Rana S V, Gupta D, Vaiphei K, Bhardwaj S, Mehta S K
Dept. of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Scand J Gastroenterol. 1995 May;30(5):451-5. doi: 10.3109/00365529509093306.
The effect of severe malnutrition has been reported by some workers, but there is a paucity of information on milder forms even though 85% of pre-school children show evidence of mild to moderate malnutrition in India.
Mild to moderate protein energy malnutrition was induced in 12 monkeys, and 12 were kept as controls. After a 30-40% reduction in body weight as compared with their controls, the animals were killed, and brush border membrane vesicles were prepared from three small parts of the small intestine. Purified vesicles were used for the assay of lactase, sucrase, maltase and glucose uptake in vitro.
The activity of lactase, sucrase, and maltase, and uptake of (U-14C)-D-glucose was decreased in all three parts of small intestine, and the lactose tolerance test result was also abnormal in the protein energy-malnourished group. On nutritional rehabilitation, the disaccharidase activities recovered completely.
This study indicates that even mild to moderate malnutrition decreases the digestion and absorption of carbohydrates throughout the small intestine, and it should not be ignored during the developing stage.
一些研究人员报道了严重营养不良的影响，但关于较轻形式的营养不良的信息却很少，尽管在印度85%的学龄前儿童有轻度至中度营养不良的迹象。
在12只猴子中诱导出轻度至中度蛋白质能量营养不良，并将12只作为对照。与对照组相比，动物体重减轻30 - 40%后，将其处死，并从小肠的三个小部位制备刷状缘膜囊泡。纯化后的囊泡用于体外乳糖酶、蔗糖酶、麦芽糖酶和葡萄糖摄取的测定。
小肠所有三个部位的乳糖酶、蔗糖酶和麦芽糖酶活性以及（U - 14C）-D -葡萄糖的摄取均降低，并且蛋白质能量营养不良组的乳糖耐量试验结果也异常。营养恢复后，双糖酶活性完全恢复。
本研究表明，即使是轻度至中度营养不良也会降低整个小肠对碳水化合物的消化和吸收，在发育阶段不应被忽视。
