Raguénès O, Mercier B, Clèdes J, Whebe B, Férec C
Centre de Biogénétique, Centre Départemental de Transfusion Sanguine, Brest, France.
Tissue Antigens. 1995 Apr;45(4):246-9. doi: 10.1111/j.1399-0039.1995.tb02447.x.
Previous studies have reported associations between HLA antigens and Idiopathic IgA Nephropathy (IgAN). Nevertheless most of the studies were performed by serology. Thus we decided to perform the HLA class II typing of 58 patients by molecular biology techniques. We report a small increase of DRB104. But the main result of our study is the identification of a strong association between HLA DQB10301 and IgAN patients with an unfavorable outcome.
先前的研究报道了HLA抗原与特发性IgA肾病（IgAN）之间的关联。然而，大多数研究是通过血清学进行的。因此，我们决定采用分子生物学技术对58例患者进行HLA II类分型。我们报告DRB104略有增加。但我们研究的主要结果是发现HLA DQB10301与预后不良的IgAN患者之间存在强关联。
