Golling M, Datsis K, Ioannidis P, von Frankenberg M, Senninger N, Herfarth C, Otto G
Sektion Lebertransplantation, Chirurgische Universitätsklinik Heidelberg.
Zentralbl Chir. 1995;120(6):445-9.
Besides primary non function (PNF), vascular complications are responsible for the majority of early surgical and interventional therapy following liver transplantation. The purpose of this study was to evaluate the influence of the variety of arterial anastomosis on postoperative morbidity and mortality. METHOD USED: In 179 liver transplantations, vascular (arterial and portal) complications within the first 3 months were analyzed with respect to the type of reconstruction. The arterial anastomoses were divided into 3 groups according to the recipient artery used [Group (I): common hepatic artery (CHA), (II): hepatic artery (HA), (III): aorta]. For statistical analysis comparison of two proportions and the logrank test were used.
The reconstruction was done primarily to the recipient CHA (69%, n = 124), less often to the HA (15%, n = 26) or directly to the aorta (16%, n = 29). The portal anastomosis-with the exception of two cases (dacron graft and internal iliac vein interposition)-was always end to end and resulted in four reinterventions (2.2%, kinking: n = 1, thrombosis: n = 3). Arterial complications (11.7%) like thrombosis, stenosis and dissection (n = 17), bleeding (n = 2) and steal phenomenon (n = 2) occurred more frequently. The difference in one year survival between patients with (n = 12/25, 47%) and without (n = 42/53, 79%) vascular complications was significant (chi 2 = 4.72, FG 1, logrank test p < 0.05).
The rate of complications causing surgical or interventional therapy is independent of the choice of arterial reconstruction. The one year survival rate in patients with vascular complications is significantly decreased.
除原发性无功能(PNF)外,血管并发症是肝移植术后早期手术和介入治疗的主要原因。本研究的目的是评估不同类型的动脉吻合术对术后发病率和死亡率的影响。使用的方法:在179例肝移植中,根据重建类型分析了前3个月内的血管(动脉和门静脉)并发症。根据所使用的受体动脉,将动脉吻合术分为3组[组(I):肝总动脉(CHA),(II):肝动脉(HA),(III):主动脉]。采用两个比例的比较和对数秩检验进行统计学分析。
重建主要针对受体CHA(69%,n = 124),较少针对HA(15%,n = 26)或直接针对主动脉(16%,n = 29)。门静脉吻合术——除2例(涤纶移植和髂内静脉插入)外——均为端端吻合,导致4次再次干预(2.2%,扭结:n = 1,血栓形成:n = 3)。动脉并发症(11.7%)如血栓形成、狭窄和夹层(n = 17)、出血(n = 2)和盗血现象(n = 2)更为常见。有(n = 12/25,47%)和无(n = 42/53,79%)血管并发症患者的一年生存率差异有统计学意义(χ2 = 4.72,FG 1,对数秩检验p < 0.05)。
导致手术或介入治疗的并发症发生率与动脉重建的选择无关。有血管并发症患者的一年生存率显著降低。