[通过离子选择性测量肝表面来检测细胞损伤是否合适？——大鼠肝移植模型研究]
[Is ion-selective measurement of the liver surface for detection of cell damage suitable?--A study of the rat liver transplantation model].
作者信息
Meyer D, Timmermann W, Thiede A
机构信息
Chirurgische Universitätsklinik Würzburg.
出版信息
Zentralbl Chir. 1995;120(6):486-9.
UNLABELLED
Aim of the study is to detect a reperfusion injury in rat liver transplantation by the Ion-selective Surface-Measurement (OMS).
METHODS
Lewis rats served as models for 30 liver transplantations with 1, 6 or 12 hrs of cold ischemia respectively. Directly before, during and after transplantation potassium- and hydrogen-concentrations were measured with the OMS and compared to transaminase values on day 1, 3 and 7 as well as to biopsies on day 3.
RESULTS
Transaminase values and histology show ischemic cell injuries correlating to the length of ischemia, whereas potassium- and hydrogen-concentrations on the organ surface do not.
CONCLUSIONS
Ischemic cell injury in the rat liver cannot be detected by the Ion-selective Measurement.
未标注
本研究的目的是通过离子选择性表面测量（OMS）检测大鼠肝移植中的再灌注损伤。
方法
将Lewis大鼠作为模型，分别进行30次肝移植，冷缺血时间分别为1、6或12小时。在移植前、移植期间和移植后，用OMS测量钾和氢的浓度，并与第1、3和7天的转氨酶值以及第3天的活检结果进行比较。
结果
转氨酶值和组织学显示缺血性细胞损伤与缺血时间长度相关，而器官表面的钾和氢浓度则不然。
结论
离子选择性测量无法检测大鼠肝脏中的缺血性细胞损伤。
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