Sickle cell anemia identified in a multiple-transfused patient through analysis of mRNA with an RT-PCR-based technique.
作者信息
Smetanina N S, Gu L H, Huisman T H
机构信息
Department of Biochemistry, Medical College of Georgia, Augusta 30912-2100, USA.
出版信息
Acta Haematol. 1995;93(2-4):105-7. doi: 10.1159/000204121.
PMID:7639050
Abstract
We report the identification of an Hb S homozygosity in a 29-year-old multiple-transfused patient with severe kidney disease using a new reverse-transcription polymerase chain reaction (RT-PCR) technique with mRNA as starting template. The procedure requires considerably less time than sequencing of genomic DNA and is recommended for use in the diagnosis of Hb S and other hemoglobinopathies.
摘要
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