Cecchin F, Johnsrude C L, Perry J C, Friedman R A
Division of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas, USA.
Am J Cardiol. 1995 Aug 15;76(5):386-91. doi: 10.1016/s0002-9149(99)80106-4.
The purpose of this study was to determine the effects of newer Fontan modifications (lateral tunnel with or without fenestration) and patient's age at surgery on the incidence and impact of symptomatic postoperative early and intermediate arrhythmias. Modifications to the Fontan procedure are used to decrease postoperative complications, and the Fontan procedure is now being performed on younger patients to reduce age-related changes in ventricular function. A retrospective review was done of the medical records of 151 consecutive patients, ranging in age from 1 to 49 years, who underwent a Fontan procedure at Texas Children's Hospital between 1987 and 1993. Risk factors were identified for early and intermediate arrhythmias. Age at time of the procedure was an independent predictor of early atrial arrhythmias (p = 0.03), ventricular arrhythmias (p = 0.003), and junctional ectopic tachycardia (JET) (p = 0.05). We found that the older the patient at surgery, the higher the incidence of atrial and ventricular arrhythmias, whereas the younger the patient, the higher the incidence of JET. Using Cox's proportional-hazards model, the risk of intermediate atrial arrhythmias after lateral tunnel modification was 1/3 that after atriopulmonary connection. Younger patients who underwent the Fontan procedure had a lower risk for early atrial and ventricular arrhythmia but an increased risk for JET. The lateral tunnel modification can be performed in order to reduce the risk of intermediate atrial arrhythmias.
本研究的目的是确定新型Fontan术式改良(带或不带开窗的侧隧道术式)以及手术时患者年龄对术后早期和中期有症状心律失常的发生率及影响。对Fontan手术进行改良是为了减少术后并发症,目前对年轻患者实施Fontan手术是为了减少与年龄相关的心室功能变化。对1987年至1993年间在德克萨斯儿童医院接受Fontan手术的151例年龄在1至49岁之间的连续患者的病历进行了回顾性分析。确定了早期和中期心律失常的危险因素。手术时的年龄是早期房性心律失常(p = 0.03)、室性心律失常(p = 0.003)和交界性异位性心动过速(JET)(p = 0.05)的独立预测因素。我们发现,手术时患者年龄越大,房性和室性心律失常的发生率越高,而患者年龄越小,JET的发生率越高。使用Cox比例风险模型,侧隧道改良术后中期房性心律失常的风险是心房肺连接术后的1/3。接受Fontan手术的年轻患者早期房性和室性心律失常的风险较低,但JET的风险增加。可以进行侧隧道改良以降低中期房性心律失常的风险。