Dalal B I, Keown P A, Paraskevas F, Williams G, Johnston J B
Division of Hematopathology, Vancouver General Hospital, BC, Canada.
Am J Hematol. 1995 Aug;49(4):349-52. doi: 10.1002/ajh.2830490415.
We report a patient with acute large granular lymphocyte (LGL) leukemia, presenting as acute myelofibrosis (AMF). The leukemic cells were immature T-cells (CD5+, CD7+, CD16-, CD56-, CD57-, and CD41-), had monosomy 7, and secreted large amounts of Transforming Growth Factor-beta 1(TGF-beta 1). The serum levels of interleukins (IL)-2, -2R, -6 and -8 were elevated, while the IL-1 beta, IL-4, and tumor necrosis factor-alpha were normal.
我们报告了一例急性大颗粒淋巴细胞（LGL）白血病患者，其表现为急性骨髓纤维化（AMF）。白血病细胞为未成熟T细胞（CD5+、CD7+、CD16-、CD56-、CD57-和CD41-），有7号染色体单体，并分泌大量转化生长因子-β1（TGF-β1）。白细胞介素（IL）-2、-2R、-6和-8的血清水平升高，而IL-1β、IL-4和肿瘤坏死因子-α水平正常。
