Fozard J R
Sandoz Pharma Ltd., Basel, Switzerland.
Arch Int Pharmacodyn Ther. 1995 Jan-Feb;329(1):111-9.
The evidence for an involvement of 5-hydroxytryptamine (5-HT) and nitric oxide (NO) in the initiation of migraine is reviewed. Based on this, the following scenario is proposed. Endogenous 5-HT, arising perhaps from platelets but more likely from perivascular 5-HT-containing neurons in response to different types of "stress", would activate 5-HT2B/5-HT2C receptors on endothelial cells of the cerebral vasculature to release NO. Nitric oxide would, by directly activating sensory neurons, induce neurotransmitter release, plasma extravasation, pain and hyperalgesia. The result would be induction of the "sterile" inflammatory response, believed to be the key step in the development of migraine.
本文综述了5-羟色胺（5-HT）和一氧化氮（NO）参与偏头痛发作的证据。基于此，提出了以下设想。内源性5-HT可能源于血小板，但更可能源于血管周围含5-HT的神经元，以应对不同类型的“应激”，它会激活脑血管内皮细胞上的5-HT2B/5-HT2C受体以释放NO。一氧化氮会通过直接激活感觉神经元，诱导神经递质释放、血浆外渗、疼痛和痛觉过敏。其结果将是引发“无菌性”炎症反应，这被认为是偏头痛发展的关键步骤。
