Clément S, Delcros J G, Basu H S, Quash G, Marton L J, Feuerstein B G
Laboratoire d'Immunochimie INSERM C.J.F. 89-05, Faculté de Médecine Lyon Sud, Oullins, France.
Biochem J. 1995 Aug 1;309 ( Pt 3)(Pt 3):787-91. doi: 10.1042/bj3090787.
The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. We have studied the ability of various polyamine analogues to inhibit cell growth and induce haemoglobin production. Polyamine analogues with free terminal amino groups were good inducers of haemoglobin production in MEL cells. Haemoglobin levels correlated with the number of positive charges: pentamines (five positive charges) were stronger inducers than tetramines (four positive charges). Compounds ethylated at their terminal amines were poor inducers of haemoglobin production but good inhibitors of MEL cell growth. These results provide evidence that polyamine analogues support specific biological functions of polyamines in MEL cells and suggest relationships between polyamine structure and function.
天然存在的多胺精胺可诱导小鼠红白血病（MEL）细胞中的血红蛋白合成。我们研究了各种多胺类似物抑制细胞生长和诱导血红蛋白产生的能力。带有游离末端氨基的多胺类似物是MEL细胞中血红蛋白产生的良好诱导剂。血红蛋白水平与正电荷数量相关：五胺（五个正电荷）比四胺（四个正电荷）是更强的诱导剂。末端胺基被乙基化的化合物是血红蛋白产生的弱诱导剂，但却是MEL细胞生长的良好抑制剂。这些结果提供了证据，表明多胺类似物支持多胺在MEL细胞中的特定生物学功能，并暗示了多胺结构与功能之间的关系。
