芳香化酶抑制剂盐酸法倔唑预防雌性大鼠自发性肿瘤
Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor.
作者信息
Gunson D E, Steele R E, Chau R Y
机构信息
Division of Preclinical Safety, Ciba-Geigy Corporation, Summit, New Jersey 07901, USA.
出版信息
Br J Cancer. 1995 Jul;72(1):72-5. doi: 10.1038/bjc.1995.279.
Abstract
Mammary tumours are oestrogen dependent in female Sprague-Dawley rats and in a significant proportion of women, so pharmacological treatment to inhibit oestrogen production is a valuable therapeutic measure to prevent or slow the progression of disease. Here we show that a non-steroidal aromatase inhibitor, which competitively inhibits the conversion of androstenedione to oestrone, prevents the development of both benign and malignant spontaneous mammary neoplasms in female Sprague-Dawley ats. It also slows the spontaneous development of pituitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats.
摘要
乳腺肿瘤在雌性斯普拉格-道利大鼠以及相当一部分女性中对雌激素依赖，因此抑制雌激素生成的药物治疗是预防或减缓疾病进展的一项重要治疗措施。在此我们表明，一种非甾体芳香化酶抑制剂，它竞争性抑制雄烯二酮向雌酮的转化，可预防雌性斯普拉格-道利大鼠良性和恶性自发性乳腺肿瘤的发生。它还能减缓雌性大鼠垂体远侧部腺瘤的自然发生，并降低雄性和雌性大鼠自发性肝细胞肿瘤的发生率。
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