Phillips M B, Flamant F, Sommelet-Olive D, Pinkerton C R
Department of Paediatrics, Royal Marsden Hospital, Sutton, Surrey, U.K.
Eur J Cancer. 1995;31A(5):782-4. doi: 10.1016/0959-8049(95)00092-w.
Twenty three patients with paediatric soft tissue sarcomas who had relapsed or refractory disease were treated with a rapid schedule of intravenous etoposide (100 mg/m2 daily on three consecutive days, weekly over 3 weeks). The regimen was well tolerated with predictable myelotoxicity. In 19 patients with rhabdomyosarcoma, there was a response rate of 42%. This appears to be better than previously reported with conventional three weekly schedules. These data indicate that for rhabdomyosarcoma, as for some other tumours, a divided dose regimen may be the optimal schedule and is worthy of further evaluation.
23例小儿软组织肉瘤复发或难治性疾病患者接受了快速静脉注射依托泊苷方案治疗（连续3天每天100mg/m²，3周内每周重复）。该方案耐受性良好，骨髓毒性可预测。在19例横纹肌肉瘤患者中，缓解率为42%。这似乎优于先前报道的传统每三周一次的方案。这些数据表明，对于横纹肌肉瘤以及其他一些肿瘤，分次给药方案可能是最佳方案，值得进一步评估。
