Morgan R J, Pollard B J
University Department of Anaesthesia, Manchester Royal Infirmary.
Br J Anaesth. 1995 Jun;74(6):651-4. doi: 10.1093/bja/74.6.651.
Fifty neurosurgical patients were given loading doses of vecuronium 0.1 mg kg-1 followed by boluses of 1, 2 or 4 mg after return of T1 of the train-of-four. Neuromuscular function was assessed simultaneously by palpation of the great toe after peripheral nerve stimulation of the lateral popliteal nerve using a handheld nerve stimulator and also using a Relaxograph attached to one arm. The time taken for the return of T1 after the bolus dose was recorded and an infusion of vecuronium was begun and subsequently adjusted to maintain steady state neuromuscular block. It was possible to predict the infusion rate of vecuronium from the duration of action of a 2-mg or 4-mg but not a 1-mg bolus dose using the handheld stimulator. The infusion rate could also be predicted from the duration of action of the initial loading dose.
五十名神经外科患者先给予维库溴铵负荷剂量0.1毫克/千克，随后在四个成串刺激的T1恢复后分别给予1毫克、2毫克或4毫克的单次推注剂量。使用手持式神经刺激器对外侧腘神经进行外周神经刺激后，通过触诊拇趾同时评估神经肌肉功能，同时也使用连接在一只手臂上的松弛描记器进行评估。记录推注剂量后T1恢复所需的时间，开始输注维库溴铵，随后进行调整以维持稳定状态的神经肌肉阻滞。使用手持式刺激器时，根据2毫克或4毫克而非1毫克推注剂量的作用持续时间可以预测维库溴铵的输注速率。输注速率也可以根据初始负荷剂量的作用持续时间进行预测。
