Fitzpatrick K T, Black G W, Crean P M, Mirakhur R K
Intensive Care Unit, Royal Belfast Hospital for Sick Children, Northern Ireland.
Can J Anaesth. 1991 Mar;38(2):169-74. doi: 10.1007/BF03008139.
Facilitation of mechanical ventilation of the lungs using an infusion of vecuronium in 11 infants and children and four neonates in an intensive care unit is described. A loading dose of vecuronium of 0.1 mg.kg-1 was followed by an infusion at an initial rate of 0.1 mg.kg-1.hr-1. The infusion rate was adjusted to maintain a neuromuscular block of approximately 90% as assessed by the presence of one response to a train-of-four stimulation. The duration of the infusions varied from 9.5 to 179 hr. The mean dose of vecuronium administered was 0.14 mg.kg-1.hr-1 (+/- 0.05, SD) in the children and 0.11 mg.kg-1.hr-1 (+/- 0.05) in the neonates. Mean recovery times from the time of stopping the infusion until absence of apparent fade in response to tetanic stimulation were 51.7 (+/- 17.6) and 46.8 (+/- 16.5) min for the children and neonates respectively. No adverse cardiovascular or toxic effects were noted. This technique of vecuronium infusion to facilitate mechanical ventilation of the lungs is feasible and satisfactory in clinical use.
描述了在重症监护病房中，对11名婴幼儿和4名新生儿输注维库溴铵以促进肺机械通气的情况。先给予0.1mg.kg-1的维库溴铵负荷剂量，随后以0.1mg.kg-1.hr-1的初始速率进行输注。根据四个成串刺激出现一次反应来评估，调整输注速率以维持约90%的神经肌肉阻滞。输注持续时间从9.5小时至179小时不等。儿童给予维库溴铵的平均剂量为0.14mg.kg-1.hr-1（±0.05，标准差），新生儿为0.11mg.kg-1.hr-1（±0.05）。从停止输注到对强直刺激无明显衰减反应的平均恢复时间，儿童为51.7（±17.6）分钟，新生儿为46.8（±16.5）分钟。未观察到不良心血管或毒性作用。这种输注维库溴铵以促进肺机械通气的技术在临床应用中是可行且令人满意的。
