Hartikainen K, Rorarius M, Mäkelä K, Peräkylä J, Varila E, Jäntti V
Department of Clinical Neurophysiology, Tampere University Hospital, Finland.
Br J Anaesth. 1995 Jun;74(6):681-5. doi: 10.1093/bja/74.6.681.
We studied EEG reactivity to visual stimuli during deep isoflurane (1.5-2.05 vol% end-tidal concentration) anaesthesia. Twelve patients were anaesthetized with isoflurane until burst suppression occurred in the EEG. Red LED goggles were used to give visual stimulation of 60 flashes, 4-ms duration each, at a frequency of 20 Hz. The stimuli, 3-strains of flashes, were given at random intervals. Both onset and offset of stimulation evoked bursts. The latency of visually evoked bursts was comparable with long latency evoked potentials, which are known to be related to cognitive processing. Our data showed that the central nervous system reacts strongly to photic stimulation during deep anaesthesia.
我们研究了在深度异氟烷（呼气末浓度为1.5 - 2.05体积%）麻醉期间脑电图（EEG）对视觉刺激的反应。12名患者用异氟烷麻醉，直至脑电图出现爆发抑制。使用红色发光二极管护目镜以20Hz的频率进行60次闪光的视觉刺激，每次闪光持续时间为4毫秒。这3组闪光刺激以随机间隔给予。刺激的开始和结束均诱发了爆发。视觉诱发爆发的潜伏期与已知与认知加工有关的长潜伏期诱发电位相当。我们的数据表明，在深度麻醉期间中枢神经系统对光刺激有强烈反应。
