Hille-Rehfeld A
Department of Biochemistry and Molecular Cell Biology, Universität Göttingen, Germany.
Biochim Biophys Acta. 1995 Jul 17;1241(2):177-94. doi: 10.1016/0304-4157(95)00004-b.
Mannose 6-phosphate receptors have been intensively studied with regard to their genomic organization, protein structure, ligand binding properties, intracellular trafficking and sorting functions. That their main function is sorting of newly synthesized lysosomal enzymes is commonly accepted, but much more remains to be learned about their precise recycling pathways and the mechanisms which regulate their vesicular transport. Additional functions have been reported, e.g., export of newly synthesized lysosomal enzymes from the cell by MPR 46 or a--probably indirect--participation in growth factor-mediated signal transduction by MPR 300. To understand the physiological relevance of these observations will be a challenge for future research.
甘露糖6-磷酸受体在基因组组织、蛋白质结构、配体结合特性、细胞内运输和分选功能等方面已得到深入研究。人们普遍认为其主要功能是对新合成的溶酶体酶进行分选，但关于其精确的再循环途径以及调节其囊泡运输的机制，仍有许多有待了解。还报道了其他功能，例如，MPR 46介导新合成的溶酶体酶从细胞中输出，或者MPR 300可能间接参与生长因子介导的信号转导。理解这些观察结果的生理相关性将是未来研究的一项挑战。
