Pontoriero R, Tonelli M P, Carnevale G, Mombelli A, Nyman S R, Lang N P
University of Berne, School of Dental Medicine, Switzerland.
Clin Oral Implants Res. 1994 Dec;5(4):254-9. doi: 10.1034/j.1600-0501.1994.050409.x.
The purpose of this study was to compare the clinical and microbiological (microscopic) parameters during the development of experimental gingivitis and experimental peri-implant mucositis. Twenty partially edentulous patients were treated for moderate to advanced periodontal disease. Following active periodontal therapy consisting of motivation, instruction in oral hygiene practices, scaling and root planing and periodontal surgery where indicated, IMZ oral implants were incorporated in posterior edentulous areas. After 3 months of healing, the prosthetic abutments were connected, and the patients were closely supervised for another 2 months of healing. At this time, baseline data were obtained. Re-examinations were scheduled at 3 and 6 months. Following this, the patients were asked to refrain from oral hygiene practices for 3 weeks. At all examinations including the end of the period of no oral hygiene, the following clinical parameters were obtained: Plaque Index, Gingival Index and Sulcus Bleeding Index, all modified by Mombelli et al. (1987), probing pocket depths and recession in mm. Furthermore, submucosal/subgingival plaque samples were obtained and analyzed using phase contrast microscopy. At the end of the 3-week period of plaque accumulation, optimal oral hygiene was reinstituted. There were no statistically significant differences between the mean values of all parameters at implant compared to tooth sites at any observation periods. The period of no oral hygiene demonstrated a similar cause-effect relationship between the accumulation of bacterial plaque and the development of peri-implant mucositis as established for the gingival units by the experimental gingivitis model.
本研究的目的是比较实验性牙龈炎和实验性种植体周围黏膜炎发展过程中的临床和微生物学（显微镜下）参数。20例部分牙列缺失患者接受了中度至重度牙周病治疗。在进行包括动机激发、口腔卫生实践指导、龈上洁治和根面平整以及必要时的牙周手术等积极的牙周治疗后，将IMZ口腔种植体植入后牙无牙区。愈合3个月后，连接修复基台，患者在接下来的2个月愈合期内接受密切监测。此时获取基线数据。在3个月和6个月安排复查。在此之后，要求患者3周内不进行口腔卫生护理。在包括不进行口腔卫生护理期结束在内的所有检查中，获取以下临床参数：均由蒙贝利等人（1987年）改良的菌斑指数、牙龈指数和龈沟出血指数，以毫米为单位的探诊深度和牙龈退缩。此外，获取黏膜下/龈下菌斑样本并使用相差显微镜进行分析。在3周菌斑积聚期结束时，恢复最佳口腔卫生护理。在任何观察期，种植体部位与牙位所有参数的平均值之间均无统计学显著差异。不进行口腔卫生护理期显示，细菌菌斑积聚与种植体周围黏膜炎发展之间存在与实验性牙龈炎模型为牙龈单位所确立的类似因果关系。
