二腺苷多磷酸：它们的生物学和药理学意义。
Diadenosine polyphosphates: their biological and pharmacological significance.
作者信息
Baxi M D, Vishwanatha J K
机构信息
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha 68198-4525, USA.
出版信息
J Pharmacol Toxicol Methods. 1995 Jun;33(3):121-8. doi: 10.1016/1056-8719(94)00127-p.
Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous in bacteria to mammals. In recent years, the diadenosine polyphosphates have received considerable attention in view of their multiple biological activities and potential pharmacological activities. Diadenosine polyphosphates have been identified as modulators of cardiovascular and neurotransmitter-like activities in recent years, besides their previously described role in cell proliferation and as signal molecules when cells are undergoing stress. Diadenosine polyphosphates and their synthetic analogues are being evaluated for their potential as pharmacological agents. This article discusses the various biological functions and physiological significance of the diadenosine polyphosphates.
二腺苷多磷酸是一类二核苷多磷酸的成员，在细菌到哺乳动物中普遍存在。近年来，鉴于其二腺苷多磷酸具有多种生物活性和潜在的药理活性，它们受到了相当多的关注。近年来，二腺苷多磷酸除了在细胞增殖中以及在细胞承受压力时作为信号分子的先前描述的作用外，还被确定为心血管和神经递质样活性的调节剂。二腺苷多磷酸及其合成类似物正在作为潜在的药物进行评估。本文讨论了二腺苷多磷酸的各种生物学功能和生理意义。
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