Lansdown A B, Sirivongs D, Vuttivirojana A
Charing Cross and Westminster Medical School, London, England.
ASAIO J. 1995 Apr-Jun;41(2):202-4.
Inbred male Wistar rats were implanted subcutaneously with samples of Dacron and Silastic tubing as used in Tenckhoff catheters for peritoneal dialysis, to evaluate their capacity to evoke toxic reactions. Implants of Dacron induced a modest to severe granulomatous reaction with giant cell formation persisting for at least 30 days. Thereafter, this reaction subsided, with Dacron fibers being surrounded by fibrous sheaths. Silastic tubing induced a mild local reaction that regressed by day 10. Predictably, adverse reactions, including erosions, abscesses, and prolonged inflammatory changes noted in clinical patients implanted with Tenckhoff catheters may be attributable to misplacements of the catheters, recurrent infections, or toxic materials from extraneous sources, but not the materials used.
将用于腹膜透析的Tenckhoff导管中的涤纶和硅橡胶管样本皮下植入近交系雄性Wistar大鼠体内，以评估它们引发毒性反应的能力。涤纶植入物引发了中度至重度的肉芽肿反应，并伴有巨细胞形成，这种反应持续了至少30天。此后，这种反应消退，涤纶纤维被纤维鞘包围。硅橡胶管引发了轻微的局部反应，在第10天时消退。可以预见的是，在植入Tenckhoff导管的临床患者中观察到的不良反应，包括糜烂、脓肿和长期炎症变化，可能归因于导管位置不当、反复感染或来自外部来源的有毒物质，而不是所用的材料。
